Epilepsy is broadly characterized by aberrant neuronal excitability. Glutamate is the
predominant excitatory neurotransmitter in the adult mammalian brain; thus, much of past …

The neurotransmitter transporters (NTTs) belonging to the solute carrier 6 (SLC6) gene
family (also referred to as the neurotransmitter-sodium-symporter family or Na+/Cl …

Abstract γ-Aminobutyric acid (GABA) transporter 1 (GAT1) regulates neuronal excitation of
the central nervous system by clearing the synaptic cleft of the inhibitory neurotransmitter …

Glutamate and GABA are the quantitatively major neurotransmitters in the brain mediating
excitatory and inhibitory signaling, respectively. These amino acids are metabolically …

The extracellular levels of γ-aminobutyric acid (GABA), the main inhibitory neurotransmitter
in the mammalian cerebral cortex, are regulated by specific high-affinity, Na+/Cl− dependent …

The synthesis, release, reuptake, and metabolism of the excitatory and inhibitory
neurotransmitters glutamate and GABA, respectively, are tightly controlled. Given the role …

Synaptic regulation of the primary inhibitory neurotransmitter γ-aminobutyric acid (GABA) is
essential for brain function. Cerebral GABA homeostasis is tightly regulated through multiple …

The interplay between excitatory and inhibitory circuits underlies the brain's processes and
their dysregulation has been linked to cognitive decline, psychiatric disorders and epilepsy …

During the past few decades of astrocyte research it has become increasingly clear that
astrocytes have taken a central position in all central nervous system activities. Much of our …

Epileptic seizure activity is associated with an imbalance between excitatory and inhibitory
synaptic activities. The latter is mediated by GABA, and several currently used antiepileptic …