Wind-up is a frequency-dependent increase in the excitability of spinal cord neurones,
evoked by electrical stimulation of afferent C-fibres. Although it has been studied over the …

Movement is accomplished by the controlled activation of motor unit populations. Our
understanding of motor unit physiology has been derived from experimental work on the …

Movement, the fundamental component of behavior and the principal extrinsic action of the
brain, is produced when skeletal muscles contract and relax in response to patterns of action …

The dendrites of motoneurons are not, as once thought, passive conduits for synaptic inputs.
Instead they have voltage‐dependent channels that provide the capacity to generate a very …

Motor fatigue induced by physical activity is an everyday experience characterized by a
decreased capacity to generate motor force. Factors in both muscles and the central nervous …

Communication between neurons can occur chemically via synaptic transmission. This
communication process begins when an invading depolarization opens voltage-gated …

We examined the modulation of persistent inward currents (PICs) by serotonin (5-HT) in
spinal motoneurons of normal and chronic spinal rats. PICs are composed of both a TTX …

This chapter summarizes a number of factors that control the``input–output''function across
the motoneurons (MNs) comprising a single spinal motor nucleus. The main focus is on …

Months after sacral spinal transection in rats (chronic spinal rats), motoneurons below the
injury exhibit large, low-threshold persistent inward currents (PICs), composed of persistent …

▪ Abstract A fundamental problem in neuroscience is understanding how a neuron
transduces synaptic input into action potentials. The dendrites form the substrate for …