Biology and hemodynamics of aneurysm rupture

CA Chitwood, ED Shih, O Amili… - Neurosurgery …, 2022 - neurosurgery.theclinics.com
What leads to aneurysm rupture versus stabilization is a question that has perplexed
researchers for decades, the answer would unquestionably influence how aneurysms are …

Peripheral macrophages in the development and progression of structural cerebrovascular pathologies

DC Lauzier, AI Srienc, AK Vellimana… - Journal of Cerebral …, 2024 - journals.sagepub.com
The human cerebrovascular system is responsible for maintaining neural function through
oxygenation, nutrient supply, filtration of toxins, and additional specialized tasks. While the …

Profiling of circulating gene expression reveals molecular signatures associated with intracranial aneurysm rupture risk

KE Poppenberg, A Chien, BA Santo, L Chaves… - Molecular diagnosis & …, 2023 - Springer
Background Following detection, rupture risk assessment for intracranial aneurysms (IAs) is
critical. Towards molecular prognostics, we hypothesized that circulating blood RNA …

Dysregulated genes and signaling pathways in the formation and rupture of intracranial aneurysm

M Kumar, K Patel, S Chinnapparaj, T Sharma… - Translational Stroke …, 2024 - Springer
Intracranial aneurysm (IA) has the potential to rupture. Despite scientific advances, we are
still not in a position to screen patients for IA and identify those at risk of rupture. It is critical …

RNA expression signatures of intracranial aneurysm growth trajectory identified in circulating whole blood

KE Poppenberg, A Chien, BA Santo, AA Baig… - Journal of Personalized …, 2023 - mdpi.com
After detection, identifying which intracranial aneurysms (IAs) will rupture is imperative. We
hypothesized that RNA expression in circulating blood reflects IA growth rate as a surrogate …

RNA sequencing data from human intracranial aneurysm tissue reveals a complex inflammatory environment associated with rupture

VM Tutino, HR Zebraski, H Rajabzadeh-Oghaz… - Molecular Diagnosis & …, 2021 - Springer
Background Intracranial aneurysm (IA) rupture leads to deadly subarachnoid hemorrhages.
However, the mechanisms leading to rupture remain poorly understood. Altered gene …

Identification of a 14-gene prognostic signature for diffuse large B cell lymphoma (DLBCL)

P Feng, H Li, J Pei, Y Huang, G Li - Frontiers in Genetics, 2021 - frontiersin.org
Although immunotherapy is a potential strategy to resist cancers, due to the inadequate
acknowledge, this treatment is not always effective for diffuse large B cell lymphoma …

Glypican-1 may be a plasma biomarker for predicting the rupture of small intracranial aneurysms.

C Wang, Y Han, X Li - Journal of Proteomics, 2024 - Elsevier
Currently, there are no effective methods for predicting the rupture of asymptomatic small
intracranial aneurysms (IA)(< 7 mm). In this study the aim was to identify early warning …

Vasospasm in pediatric subarachnoid hemorrhage

I Mavridis, ES Pyrgelis, E Agapiou… - CNS & Neurological …, 2024 - benthamdirect.com
Cerebral vasospasm (CV) is a common severe complication of subarachnoid hemorrhage
(SAH), a severe type of intracranial bleeding that is uncommon in children. The purpose of …

Molecular Basis of Cerebral Vasospasm: What Can We Learn from Transcriptome and Temporal Gene Expression Profiling in Intracranial Aneurysm?

M Kumar, T Sharma, K Patel… - OMICS: A Journal of …, 2024 - liebertpub.com
Cerebral vasospasm (CV) is a significant complication following aneurysmal subarachnoid
hemorrhage (aSAH), and lacks a comprehensive molecular understanding. Given the …