Glycomimetics for the inhibition and modulation of lectins
Carbohydrates are essential mediators of many processes in health and disease. They
regulate self-/non-self-discrimination, are key elements of cellular communication, cancer …
regulate self-/non-self-discrimination, are key elements of cellular communication, cancer …
Glycosaminoglycans: what remains to be deciphered?
Glycosaminoglycans (GAGs) are complex polysaccharides exhibiting a vast structural
diversity and fulfilling various functions mediated by thousands of interactions in the …
diversity and fulfilling various functions mediated by thousands of interactions in the …
Exploring multivalent carbohydrate–protein interactions by NMR
JI Quintana, U Atxabal, L Unione, A Ardá… - Chemical Society …, 2023 - pubs.rsc.org
Nuclear Magnetic Resonance (NMR) has been widely employed to assess diverse features
of glycan–protein molecular recognition events. Different types of qualitative and quantitative …
of glycan–protein molecular recognition events. Different types of qualitative and quantitative …
Multivalent glycosystems for human lectins
M Martínez-Bailén, J Rojo… - Chemical Society …, 2023 - pubs.rsc.org
Human lectins are involved in a wide variety of biological processes, both physiological and
pathological, which have attracted the interest of the scientific community working in the …
pathological, which have attracted the interest of the scientific community working in the …
The mechanistic impact of N-glycosylation on stability, pharmacokinetics, and immunogenicity of therapeutic proteins
Q Zhou, H Qiu - Journal of pharmaceutical sciences, 2019 - Elsevier
N-glycosylation is one of major post-translational modifications in nature, and it is essential
for protein structure and function. As hydrophilic moieties of glycoproteins, N-glycans play …
for protein structure and function. As hydrophilic moieties of glycoproteins, N-glycans play …
Multivalent glycans for biological and biomedical applications
Y Kim, JY Hyun, I Shin - Chemical Society Reviews, 2021 - pubs.rsc.org
Recognition of glycans by proteins plays a crucial role in a variety of physiological
processes in cells and living organisms. In addition, interactions of glycans with proteins are …
processes in cells and living organisms. In addition, interactions of glycans with proteins are …
The recognition of glycans by protein receptors. Insights from NMR spectroscopy
A Ardá, J Jiménez-Barbero - Chemical Communications, 2018 - pubs.rsc.org
Carbohydrates (glycans, saccharides, sugars) are everywhere. In fact, glycan–protein
interactions are involved in many essential processes of life and disease. The …
interactions are involved in many essential processes of life and disease. The …
Myeloid C-type lectin receptors in innate immune recognition
CR e Sousa, S Yamasaki, GD Brown - Immunity, 2024 - cell.com
C-type lectin receptors (CLRs) expressed by myeloid cells constitute a versatile family of
receptors that play a key role in innate immune recognition. Myeloid CLRs exhibit a …
receptors that play a key role in innate immune recognition. Myeloid CLRs exhibit a …
A specific, glycomimetic langerin ligand for human langerhans cell targeting
EC Wamhoff, J Schulze, L Bellmann… - ACS central …, 2019 - ACS Publications
Langerhans cells are a subset of dendritic cells residing in the epidermis of the human skin.
As such, they are key mediators of immune regulation and have emerged as prime targets …
As such, they are key mediators of immune regulation and have emerged as prime targets …
Molecular recognition in C‐type lectins: the cases of DC‐SIGN, Langerin, MGL, and L‐sectin
P Valverde, JD Martinez, FJ Cañada, A Arda… - …, 2020 - Wiley Online Library
Carbohydrates play a pivotal role in intercellular communication processes. In particular,
glycan antigens are key for sustaining homeostasis, helping leukocytes to distinguish …
glycan antigens are key for sustaining homeostasis, helping leukocytes to distinguish …