Stress is defined as a state of threatened or perceived as threatened homeostasis. The well-
tuned coordination of the stress response system is necessary for an organism to respond to …

During the past decades, the mineralocorticoid receptor (MR) has evolved from a much‐
overlooked member of the steroid hormone receptor family to an important player, not only in …

Background: Heart failure (HF) survival has improved, and nowadays, many patients with HF
die of noncardiac causes, including cancer. Our aim was to investigate whether a causal …

Stress is increasingly associated with heart dysfunction and is linked to higher mortality rates
in patients with cardiometabolic disease. Glucocorticoids are primary stress hormones that …

Age-related hearing loss (ARHL)-presbycusis-is the most prevalent neurodegenerative
disease and number one communication disorder of our aged population; and affects …

Several large clinical studies have demonstrated the important benefit of mineralocorticoid
receptor (MR) antagonists in patients with heart failure, left ventricular dysfunction after …

Mineralocorticoid receptor (MR) activation may be deleterious to the cardiovascular system,
and MR antagonists improve morbidity and mortality of patients with heart failure. However …

Primary aldosteronism, or Conn syndrome, is the most common endocrine cause of
hypertension. It is associated with a higher risk of cardiovascular, metabolic and renal …

Aldosterone is the most known mineralocorticoid hormone synthesized by the adrenal
cortex. The genomic pathway displayed by aldosterone is attributed to the mineralocorticoid …

Abstract Background In the Finerenone in Reducing Cardiovascular Mortality and Morbidity
in Diabetic Kidney Disease trial, finerenone reduced the risk of cardiovascular events in …