Tau: Enabler of diverse brain disorders and target of rapidly evolving therapeutic strategies
BACKGROUND The microtubule-associated protein tau has been implicated in the
pathogenesis of Alzheimer's disease and a range of other neurodegenerative disorders …
pathogenesis of Alzheimer's disease and a range of other neurodegenerative disorders …
Models of psychedelic drug action: modulation of cortical-subcortical circuits
Classic psychedelic drugs such as psilocybin and lysergic acid diethylamide (LSD) have
recaptured the imagination of both science and popular culture, and may have efficacy in …
recaptured the imagination of both science and popular culture, and may have efficacy in …
Dopamine and glutamate in schizophrenia: biology, symptoms and treatment
RA McCutcheon, JH Krystal, OD Howes - World Psychiatry, 2020 - Wiley Online Library
Glutamate and dopamine systems play distinct roles in terms of neuronal signalling, yet both
have been proposed to contribute significantly to the pathophysiology of schizophrenia. In …
have been proposed to contribute significantly to the pathophysiology of schizophrenia. In …
Economics and mental health: the current scenario
Economics and mental health are intertwined. Apart from the accumulating evidence of the
huge economic impacts of mental ill‐health, and the growing recognition of the effects that …
huge economic impacts of mental ill‐health, and the growing recognition of the effects that …
Methodological considerations for studying neural oscillations
T Donoghue, N Schaworonkow… - European journal of …, 2022 - Wiley Online Library
Neural oscillations are ubiquitous across recording methodologies and species, broadly
associated with cognitive tasks, and amenable to computational modelling that investigates …
associated with cognitive tasks, and amenable to computational modelling that investigates …
Thalamic functions in distributed cognitive control
MM Halassa, S Kastner - Nature neuroscience, 2017 - nature.com
Cognition can be conceptualized as a set of algorithmic control functions whose real-time
deployment determines how an organism stores and uses information to guide thought and …
deployment determines how an organism stores and uses information to guide thought and …
Dynamic functional connectivity: promise, issues, and interpretations
The brain must dynamically integrate, coordinate, and respond to internal and external
stimuli across multiple time scales. Non-invasive measurements of brain activity with fMRI …
stimuli across multiple time scales. Non-invasive measurements of brain activity with fMRI …
The log-dynamic brain: how skewed distributions affect network operations
G Buzsáki, K Mizuseki - Nature Reviews Neuroscience, 2014 - nature.com
We often assume that the variables of functional and structural brain parameters—such as
synaptic weights, the firing rates of individual neurons, the synchronous discharge of neural …
synaptic weights, the firing rates of individual neurons, the synchronous discharge of neural …
[HTML][HTML] Scaling brain size, keeping timing: evolutionary preservation of brain rhythms
Despite the several-thousand-fold increase of brain volume during the course of mammalian
evolution, the hierarchy of brain oscillations remains remarkably preserved, allowing for …
evolution, the hierarchy of brain oscillations remains remarkably preserved, allowing for …
[HTML][HTML] Prefrontal parvalbumin neurons in control of attention
H Kim, S Ährlund-Richter, X Wang, K Deisseroth… - Cell, 2016 - cell.com
While signatures of attention have been extensively studied in sensory systems, the neural
sources and computations responsible for top-down control of attention are largely …
sources and computations responsible for top-down control of attention are largely …