Stroke is one of the leading causes of death and disability worldwide. The long‐standing
dogma that stroke is exclusively a vascular disease has been questioned by extensive …

As the organ with the highest demand for oxygen, the brain has a poor tolerance to ischemia
and hypoxia. Despite severe ischemia/hypoxia induces the occurrence and development of …

Lymphocytes infiltrate the stroke core and penumbra and often exacerbate cellular injury. B
cells, however, are lymphocytes that do not contribute to acute pathology but can support …

B cells, also known as B lymphocytes or lymphoid lineage cells, are a historically
understudied cell population with regard to brain-related injuries and diseases. However, an …

Recent studies have highlighted the deleterious contributions of B cells to post-stroke
recovery and cognitive decline. Different B cell subsets have been proposed on the basis of …

Aims Remote ischemic preconditioning (RIPC) of a limb is a clinically feasible strategy to
protect against ischemia–reperfusion injury after stroke. However, the mechanism …

Stroke, in association with its complications, is one of the leading causes of mortality and
morbidity worldwide. Cerebral ischemia triggers an inflammatory response in the brain that …

Hypoxia is a common hallmark of healthy tissues in physiological states or chronically
inflamed tissues in pathological states. Mammalian cells sense and adapt to hypoxia mainly …

Background Ischemic stroke is a leading cause of mortality worldwide, largely due to the
inflammatory response to brain ischemia during post-stroke reperfusion. Despite ongoing …

Stroke, which occurs during a loss of blood flow to the brain, is a global disease that
accounts for 10% of yearly mortality. But stroke is also a leading cause of long-term adult …