[HTML][HTML] Regulation of immune responses by the airway epithelial cell landscape
The community of cells lining our airways plays a collaborative role in the preservation of
immune homeostasis in the lung and provides protection from the pathogens and pollutants …
immune homeostasis in the lung and provides protection from the pathogens and pollutants …
[PDF][PDF] Mucosal immune responses to infection and vaccination in the respiratory tract
The lungs are constantly exposed to inhaled debris, allergens, pollutants, commensal or
pathogenic microorganisms, and respiratory viruses. As a result, innate and adaptive …
pathogenic microorganisms, and respiratory viruses. As a result, innate and adaptive …
[PDF][PDF] CXCR6 positions cytotoxic T cells to receive critical survival signals in the tumor microenvironment
M Di Pilato, R Kfuri-Rubens, JN Pruessmann, AJ Ozga… - Cell, 2021 - cell.com
Cytotoxic T lymphocyte (CTL) responses against tumors are maintained by stem-like
memory cells that self-renew but also give rise to effector-like cells. The latter gradually lose …
memory cells that self-renew but also give rise to effector-like cells. The latter gradually lose …
[HTML][HTML] Tissue resident memory T cells in the respiratory tract
MZM Zheng, LM Wakim - Mucosal immunology, 2022 - Elsevier
Owing to their capacity to rapidly spread across the population, airborne pathogens
represent a significant risk to global health. Indeed, several of the past major global …
represent a significant risk to global health. Indeed, several of the past major global …
[HTML][HTML] Sphingosine 1-phosphate receptor 5 (S1PR5) regulates the peripheral retention of tissue-resident lymphocytes
Tissue-resident memory T (TRM) cells provide long-lasting immune protection. One of the
key events controlling TRM cell development is the local retention of TRM cell precursors …
key events controlling TRM cell development is the local retention of TRM cell precursors …
[HTML][HTML] Airway-resident T cells from unexposed individuals cross-recognize SARS-CoV-2
T cells can contribute to clearance of respiratory viruses that cause acute-resolving
infections such as SARS-CoV-2, helping to provide long-lived protection against disease …
infections such as SARS-CoV-2, helping to provide long-lived protection against disease …
[HTML][HTML] Epithelial barrier dysfunction in chronic respiratory diseases
FM Carlier, C de Fays, C Pilette - Frontiers in physiology, 2021 - frontiersin.org
Mucosal surfaces are lined by epithelial cells, which provide a complex and adaptive
module that ensures first-line defense against external toxics, irritants, antigens, and …
module that ensures first-line defense against external toxics, irritants, antigens, and …
COVID‐19 immunopathology: from acute diseases to chronic sequelae
The clinical manifestation of coronavirus disease 2019 (COVID‐19) mainly targets the lung
as a primary affected organ, which is also a critical site of immune cell activation by severe …
as a primary affected organ, which is also a critical site of immune cell activation by severe …
[HTML][HTML] Nasal epithelial barrier integrity and tight junctions disruption in allergic rhinitis: overview and pathogenic insights
Allergic rhinitis (AR) is a common disorder affecting up to 40% of the population worldwide
and it usually persists throughout life. Nasal epithelial barrier constitutes the first line of …
and it usually persists throughout life. Nasal epithelial barrier constitutes the first line of …
[HTML][HTML] CXCR6 expressing T cells: Functions and role in the control of tumors
N Mabrouk, T Tran, I Sam, I Pourmir, N Gruel… - Frontiers in …, 2022 - frontiersin.org
CXCR6 is a receptor for the chemokine CXCL16, which exists as a membrane or soluble
form. CXCR6 is a marker for resident memory T (TRM) cells that plays a role in …
form. CXCR6 is a marker for resident memory T (TRM) cells that plays a role in …