Automation and data-driven design of polymer therapeutics
Polymers are uniquely suited for drug delivery and biomaterial applications due to tunable
structural parameters such as length, composition, architecture, and valency. To facilitate …
structural parameters such as length, composition, architecture, and valency. To facilitate …
Biomaterials via peptide assembly: Design, characterization, and application in tissue engineering
A core challenge in biomaterials, with both fundamental significance and technological
relevance, concerns the rational design of bioactive microenvironments. Designed properly …
relevance, concerns the rational design of bioactive microenvironments. Designed properly …
Inhibiting protein aggregation by small molecule-based colloidal nanoparticles
Conspectus Protein aggregation is associated with different human diseases such as
Alzheimer's, Huntington's, Parkinson's, diabetes type II, and cataracts. Currently no effective …
Alzheimer's, Huntington's, Parkinson's, diabetes type II, and cataracts. Currently no effective …
From small molecules to synthesized polymers: potential role in combating amyloidogenic disorders
The concept of developing novel anti-amyloid inhibitors in the scientific community has
engrossed remarkable research interests and embraced significant potential to resolve …
engrossed remarkable research interests and embraced significant potential to resolve …
Seeking regularity from irregularity: Unveiling the synthesis–nanomorphology relationships of heterogeneous nanomaterials using unsupervised machine learning
Nanoscale morphology of functional materials determines their chemical and physical
properties. However, despite increasing use of transmission electron microscopy (TEM) to …
properties. However, despite increasing use of transmission electron microscopy (TEM) to …
Nanomaterial synthesis, an enabler of amyloidosis inhibition against human diseases
Amyloid diseases are global epidemics with no cure currently available. In the past decade,
the use of engineered nanomaterials as inhibitors or probes against the pathogenic …
the use of engineered nanomaterials as inhibitors or probes against the pathogenic …
Metal-mediated nanobody assemblies as potent alleviators of human islet amyloid polypeptide aggregation
L Zhao, L Luo, F Meng - Materials Chemistry Frontiers, 2023 - pubs.rsc.org
The misfolding and aggregation of peptides and proteins into β-sheet-enriched amyloid
fibrils has been implicated in many human diseases. Inhibition of protein aggregation by …
fibrils has been implicated in many human diseases. Inhibition of protein aggregation by …
Bioinspired synthetic polymers-based inhibitors of Alzheimer's amyloid-β peptide aggregation
Alzheimer's disease (AD) is a progressive neurodegenerative disease with no current cure
and limited treatment solutions, wherefore discovering of novel therapies remains a global …
and limited treatment solutions, wherefore discovering of novel therapies remains a global …
Say no to drugs: Bioactive macromolecular therapeutics without conventional drugs
M Rütter, N Milošević, A David - Journal of Controlled Release, 2021 - Elsevier
The vast majority of nanomedicines (NM) investigated today consists of a macromolecular
carrier and a drug payload (conjugated or encapsulated), with a purpose of preferential …
carrier and a drug payload (conjugated or encapsulated), with a purpose of preferential …
Conformation-reconstructed multivalent antibody mimic for amplified mitigation of human islet amyloid polypeptide amyloidogenesis
L Zhao, S Wang, Q Hu, H Jia, Y Xin, L Luo, F Meng - Nanoscale, 2022 - pubs.rsc.org
The misfolding and aggregation of human islet amyloid polypeptide (IAPP) into β-sheet-
enriched amyloid fibrils is linked to type 2 diabetes. Antibodies are potent inhibitors of IAPP …
enriched amyloid fibrils is linked to type 2 diabetes. Antibodies are potent inhibitors of IAPP …