Tuberculosis (TB) is a serious public health problem worldwide. Its situation is worsened by
the presence of multidrug resistant (MDR) strains of Mycobacterium tuberculosis, the …

Resistance to rifampicin (RIF) is a broad subject covering not just the mechanism of clinical
resistance, nearly always due to a genetic change in the β subunit of bacterial RNA …

The rapid identification of antimicrobial resistance is essential for effective treatment of
highly resistant Mycobacterium tuberculosis. Whole-genome sequencing provides …

Tuberculosis (TB) remains one of the leading public health problems worldwide. Declared
as a global emergency in 1993 by the WHO, its control is hampered by the emergence of …

Tuberculosis (TB) is a formidable infectious disease that remains a major cause of death
worldwide today. Escalating application of genomic techniques has expedited the …

Resistance to rifampin (RIF) and rifabutin (RFB) in Mycobacterium tuberculosis is associated
with mutations within an 81-bp region of the rpoB gene (RIF resistance-determining region …

The emergence of drug-resistant strains of Mycobacterium tuberculosis is a challenge to
global tuberculosis (TB) control. Although culture-based methods have been regarded as …

Rationale: Central dogma suggests that rifampicin resistance in Mycobacterium tuberculosis
develops solely through rpoB gene mutations. Objective: To determine whether rifampicin …

Bacterial persisters are a subpopulation of cells that can tolerate lethal concentrations of
antibiotics. However, the possibility of the emergence of genetically resistant mutants from …

Multidrug-resistant (MDR) Mycobacterium tuberculosis complex (MTBC) strains represent a
major threat for tuberculosis (TB) control. Treatment of MDR-TB patients is long and less …