Novel pathways of inflammation in human fetal membranes associated with preterm birth and preterm pre-labor rupture of the membranes

R Menon, F Behnia, J Polettini… - Seminars in …, 2020 - Springer
Spontaneous preterm birth (PTB) and preterm pre-labor rupture of the membranes (pPROM)
are major pregnancy complications. Although PTB and pPROM have common etiologies …

Fetal inflammatory response at the fetomaternal interface: A requirement for labor at term and preterm

R Menon - Immunological reviews, 2022 - Wiley Online Library
Human parturition at term and preterm is an inflammatory process synchronously executed
by both fetomaternal tissues to transition them from a quiescent state t an active state of …

[图书][B] Birth as an American rite of passage

R Davis-Floyd - 2022 - taylorfrancis.com
This classic book, first published in 1992 and again in 2003, has inspired three generations
of childbearing people, birth activists and researchers, and birth practitioners—midwives …

[HTML][HTML] Fetal and maternal NLRP3 signaling is required for preterm labor and birth

K Motomura, R Romero, J Galaz, L Tao… - JCI insight, 2022 - ncbi.nlm.nih.gov
Preterm birth is the leading cause of neonatal morbidity and mortality worldwide. One of
every 4 preterm neonates is born to a mother with intra-amniotic inflammation driven by …

Deciphering maternal-fetal cross-talk in the human placenta during parturition using single-cell RNA sequencing

V Garcia-Flores, R Romero, AL Tarca… - Science translational …, 2024 - science.org
Labor is a complex physiological process requiring a well-orchestrated dialogue between
the mother and fetus. However, the cellular contributions and communications that facilitate …

PGS scaffolds promote the in vivo survival and directional differentiation of bone marrow mesenchymal stem cells restoring the morphology and function of wounded …

B Xiao, W Yang, D Lei, J Huang, Y Yin… - Advanced …, 2019 - Wiley Online Library
Intrauterine adhesion (IUA) causing infertility and recurrent miscarriage of reproductive
female mammals usually results from endometrium injury. Nevertheless, there is no efficient …

Progesterone receptor regulation of uterine adaptation for pregnancy

SP Wu, R Li, FJ DeMayo - Trends in Endocrinology & Metabolism, 2018 - cell.com
Progesterone acts through the progesterone receptor to direct physiological adaption of the
uterus in preparation and completion of pregnancy. Genome-wide transcriptome and …

Initiation of human parturition: signaling from senescent fetal tissues via extracellular vesicle mediated paracrine mechanism

R Menon - Obstetrics & gynecology science, 2019 - synapse.koreamed.org
A better understanding of the underlying mechanisms by which signals from the fetus initiate
human parturition is required. Our recent findings support the core hypothesis that oxidative …

Multifactorial regulation of myometrial contractility during pregnancy and parturition

CR Mendelson, L Gao, AP Montalbano - Frontiers in Endocrinology, 2019 - frontiersin.org
The steroid hormones progesterone (P4) and estradiol-17β (E2), produced by the placenta
in humans and the ovaries in rodents, serve crucial roles in the maintenance of pregnancy …

Targeting Toll‐like receptor‐4 to tackle preterm birth and fetal inflammatory injury

SA Robertson, MR Hutchinson, KC Rice… - Clinical & …, 2020 - Wiley Online Library
Every year, 15 million pregnancies end prematurely, resulting in more than 1 million infant
deaths and long‐term health consequences for many children. The physiological processes …