High-throughput analysis of hazards in novel food based on the density functional theory and multimodal deep learning
L Shi, W Jia, R Zhang, Z Fan, W Bian, H Mo - Food Chemistry, 2024 - Elsevier
The emergence of cultured meat presents the potential for personalized food additive
manufacturing, offering a solution to address future food resource scarcity. Processing raw …
manufacturing, offering a solution to address future food resource scarcity. Processing raw …
Digital Microfluidics for Sample Preparation in Low‐Input Proteomics
MK Steinbach, J Leipert, T Matzanke… - Small Methods, 2024 - Wiley Online Library
Low‐input proteomics, also referred to as micro‐or nanoproteomics, has become
increasingly popular as it allows one to elucidate molecular processes in rare biological …
increasingly popular as it allows one to elucidate molecular processes in rare biological …
Automated imaging and identification of proteoforms directly from ovarian cancer tissue
The molecular identification of tissue proteoforms by top-down mass spectrometry (TDMS) is
significantly limited by throughput and dynamic range. We introduce AutoPiMS, a single-ion …
significantly limited by throughput and dynamic range. We introduce AutoPiMS, a single-ion …
Influence of different sample preparation approaches on proteoform identification by top-down proteomics
Top-down proteomics using mass spectrometry facilitates the identification of intact
proteoforms, that is, all molecular forms of proteins. Multiple past advances have lead to the …
proteoforms, that is, all molecular forms of proteins. Multiple past advances have lead to the …
Digital Microfluidics and Magnetic Bead‐Based Intact Proteoform Elution for Quantitative Top‐down Nanoproteomics of Single C. elegans Nematodes
J Leipert, PT Kaulich, MK Steinbach… - Angewandte Chemie …, 2023 - Wiley Online Library
While most nanoproteomics approaches for the analysis of low‐input samples are based on
bottom‐up proteomics workflows, top‐down approaches enabling proteoform …
bottom‐up proteomics workflows, top‐down approaches enabling proteoform …
Recent advancements in subcellular proteomics: growing impact of organellar protein niches on the understanding of cell biology
V Bhushan, A Nita-Lazar - Journal of Proteome Research, 2024 - ACS Publications
The mammalian cell is a complex entity, with membrane-bound and membrane-less
organelles playing vital roles in regulating cellular homeostasis. Organellar protein niches …
organelles playing vital roles in regulating cellular homeostasis. Organellar protein niches …
Top-down proteomics
Proteoforms, which arise from post-translational modifications, genetic polymorphisms and
RNA splice variants, play a pivotal role as drivers in biology. Understanding proteoforms is …
RNA splice variants, play a pivotal role as drivers in biology. Understanding proteoforms is …
Top-Down Proteomics Analysis of Picogram-Level Complex Samples Using Spray-Capillary-Based Capillary Electrophoresis–Mass Spectrometry
Proteomics analysis of mass-limited samples has become increasingly important for
understanding biological systems in physiologically relevant contexts such as patient …
understanding biological systems in physiologically relevant contexts such as patient …
Discovery top-down proteomics in symbiotic soybean root nodules
Proteomic methods have been widely used to study proteins in complex biological samples
to understand biological molecular mechanisms. Most well-established methods (known as …
to understand biological molecular mechanisms. Most well-established methods (known as …
Laser capture microdissection and native mass spectrometry for spatially-resolved analysis of intact protein assemblies in tissue
Previously, we have shown that native ambient mass spectrometry imaging allows the
spatial mapping of folded proteins and their complexes in thin tissue sections. Subsequent …
spatial mapping of folded proteins and their complexes in thin tissue sections. Subsequent …