Human African trypanosomiasis (HAT), or sleeping sickness, is caused by Trypanosoma
brucei gambiense, which is a chronic form of the disease present in western and central …

Trypanosoma brucei is a pathogenic unicellular eukaryote that infects humans and other
mammals in sub-Saharan Africa. A central feature of trypanosome biology is the single …

Unraveling the intricate interactions between Trypanosoma brucei, the protozoan parasite
causing African trypanosomiasis, and the tsetse (Glossina) vector remains a challenge …

Adaptation to different nutritional environments is essential for life cycle completion by all
Trypanosoma brucei sub-species. In the tsetse fly vector, L-proline is among the most …

Kinetoplastids, including the human pathogens Trypanosoma brucei, Trypanosoma cruzi
and Leishmania, are the only known organisms that do not regulate the transcription of …

Tsetse flies (Glossina spp.) vector pathogenic African trypanosomes, which cause sleeping
sickness in humans and nagana in domesticated animals. Additionally, tsetse harbors 3 …

A defining feature of Trypanosoma brucei cell shape is the lateral attachment of the
flagellum to the cell body, mediated by the flagellum attachment zone (FAZ). The FAZ is a …

African trypanosomes are unicellular flagellated parasites causing trypanosomiases in
Africa, a group of severe diseases also known as sleeping sickness in human and nagana …

Elucidating the mechanism of genetic exchange is fundamental for understanding how
genes for such traits as virulence, disease phenotype, and drug resistance are transferred …

Extracellular vesicles (EV) secreted by pathogens function in a variety of biological
processes. Here, we demonstrate that in the protozoan parasite Trypanosoma brucei …