The mucus clearance system is the dominant mechanical host defense system of the human
lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid …

Background Inflammation in the lung is the body's natural response to injury. It acts to
remove harmful stimuli such as pathogens, irritants, and damaged cells and initiate the …

Cystic fibrosis (CF) is widely known as a disease of the lung, even though it is in truth a
systemic disease, whose symptoms typically manifest in gastrointestinal dysfunction first. CF …

Allergic airway disease is known to cause significant morbidity due to impaired mucociliary
clearance, however the mechanism that leads to the mucus dysfunction is not entirely …

Pathological fibrosis is the result of a failure in the wound healing process. The
comprehension and the related modeling of the different mechanisms that trigger fibrosis are …

Airway surface liquid hyperabsorption and mucus accumulation are key elements of cystic
fibrosis lung disease that can be assessed in vivo using functional imaging methods. In this …

Dehydration of mucus in the lungs of cystic fibrosis (CF) patients can inhibit mucociliary
clearance (MCC), resulting in mucus build-up and blockages. Prior mathematical models …

Cystic fibrosis (CF) disease is caused by mutations affecting the gene coding for the cystic
fibrosis transmembrane conductance regulator (CFTR), an anion channel expressed in the …

Lung diseases cause an enormous socioeconomic burden. Four of them are among the ten
most important causes of deaths worldwide: Pneumonia has the highest death toll of all …

Healthy humans have a thin layer of mucus lining the airways that protects the lungs from
inhaled particulate or pathogens. Trapped particles are conveyed up the airway tree and out …