Neurosteroids are potent and effective neuromodulators that are synthesized from
cholesterol in the brain. These agents and their synthetic derivatives influence the function of …

Memory dysfunction is a symptomatic feature of many neurologic and neuropsychiatric
disorders; however, the basic underlying mechanisms of memory and altered states of …

Evidence suggests that neuroactive steroids may be candidate modulators of schizophrenia
pathophysiology and therapeutics. We therefore investigated neuroactive steroid levels in …

The neuroactive steroid allopregnanolone (ALLO) is an endogenous positive allosteric
modulator of GABA type A receptor (GABA AR), and the down-regulation of its biosynthesis …

γ-aminobutyric acid type A (GABAA) receptors play an important role in mediating fast
synaptic inhibition in the brain. They are ubiquitously expressed in the CNS and also …

Recent findings demonstrated the dysregulation of imidazoline receptor binding sites in
major depression and their normalization by chronic treatment with antidepressants …

Benzodiazepines (BDZs) enhance GABA A receptor inhibition by direct actions on central
BDZ receptors (CBRs). Although some BDZs also bind mitochondrial receptors [translocator …

Olanzapine is a commonly used drug in the treatment of schizophrenia, but its clinical
application has been restricted by metabolic-related side effects. In order to mitigate the …

The pregnenolone-progesterone-allopregnanolone pathway is receiving increasing
attention in research on the role of neurosteroids in pathophysiology, particularly in stress …

Neurosteroids are a group of important endogenous molecules affecting many neural
functions in the brain. Increasing evidence suggests a possible role of these neurosteroids …