The ras superfamily of small gtpases in non-neoplastic cerebral diseases
L Qu, C Pan, SM He, B Lang, GD Gao… - Frontiers in molecular …, 2019 - frontiersin.org
The small GTPases from the Ras superfamily play crucial roles in basic cellular processes
during practically the entire process of neurodevelopment, including neurogenesis …
during practically the entire process of neurodevelopment, including neurogenesis …
Molecules, mechanisms, and disorders of self-domestication: keys for understanding emotional and social communication from an evolutionary perspective
The neural crest hypothesis states that the phenotypic features of the domestication
syndrome are due to a reduced number or disruption of neural crest cells (NCCs) migration …
syndrome are due to a reduced number or disruption of neural crest cells (NCCs) migration …
The small GTPase Rit2 modulates LRRK2 kinase activity, is required for lysosomal function and protects against alpha-synuclein neuropathology
J Obergasteiger, AM Castonguay, S Pizzi… - npj Parkinson's …, 2023 - nature.com
In Parkinson's disease (PD) misfolded alpha-synuclein (aSyn) accumulates in the substantia
nigra, where dopaminergic neurons are progressively lost. The mechanisms underlying …
nigra, where dopaminergic neurons are progressively lost. The mechanisms underlying …
Application of single-nucleotide polymorphisms in the diagnosis of autism spectrum disorders: a preliminary study with artificial neural networks
Autism spectrum disorder (ASD) includes different neurodevelopmental disorders
characterized by deficits in social communication, and restricted, repetitive patterns of …
characterized by deficits in social communication, and restricted, repetitive patterns of …
[HTML][HTML] RIT2 regulates autophagy lysosomal pathway induction and protects against α-synuclein pathology in a cellular model of Parkinson's disease
Substantial work has been devoted to better understand the contribution of the myriad of
genes that may underly the development of Parkinson's disease (PD) and their role in …
genes that may underly the development of Parkinson's disease (PD) and their role in …
Conditional, inducible gene silencing in dopamine neurons reveals a sex-specific role for Rit2 GTPase in acute cocaine response and striatal function
Dopamine (DA) signaling is critical for movement, motivation, and addictive behavior. The
neuronal GTPase, Rit2, is enriched in DA neurons (DANs), binds directly to the DA …
neuronal GTPase, Rit2, is enriched in DA neurons (DANs), binds directly to the DA …
DIP2C polymorphisms are implicated in susceptibility and clinical phenotypes of autism spectrum disorder
Y Li, C Sun, Y Guo, S Qiu, Y Li, Y Liu, W Zhong… - Psychiatry …, 2022 - Elsevier
Background Disco-interacting protein 2 C (DIP2C) has recently been reported as a new
susceptibility gene for autism spectrum disorder (ASD) in a genome-wide association study …
susceptibility gene for autism spectrum disorder (ASD) in a genome-wide association study …
Dopamine transporter trafficking and Rit2 GTPase: Mechanism of action and in vivo impact
Following its evoked release, dopamine (DA) signaling is rapidly terminated by presynaptic
reuptake, mediated by the cocaine-sensitive DA transporter (DAT). DAT surface availability …
reuptake, mediated by the cocaine-sensitive DA transporter (DAT). DAT surface availability …
Silencing Parkinson's risk allele Rit2 sex-specifically compromises motor function and dopamine neuron viability
Parkinson's disease (PD) is the second most prevalent neurodegenerative disease and
arises from dopamine (DA) neuron death selectively in the substantia nigra pars compacta …
arises from dopamine (DA) neuron death selectively in the substantia nigra pars compacta …
Presynaptic Gq-coupled receptors drive biphasic dopamine transporter trafficking that modulates dopamine clearance and motor function
PJ Kearney, NC Bolden, E Kahuno, TL Conklin… - Journal of Biological …, 2023 - ASBMB
Extracellular dopamine (DA) levels are constrained by the presynaptic DA transporter (DAT),
a major psychostimulant target. Despite its necessity for DA neurotransmission, DAT …
a major psychostimulant target. Despite its necessity for DA neurotransmission, DAT …