Epithelial barrier hypothesis: effect of the external exposome on the microbiome and epithelial barriers in allergic disease

Z Celebi Sozener, B Ozdel Ozturk, P Cerci, M Turk… - Allergy, 2022 - Wiley Online Library
Environmental exposure plays a major role in the development of allergic diseases. The
exposome can be classified into internal (eg, aging, hormones, and metabolic processes) …

CCL13 and human diseases

L Li, F Dai, L Wang, Y Sun, L Mei, Y Ran… - Frontiers in …, 2023 - frontiersin.org
CCL13/MCP-4 belongs to the CC chemokine family, which induces chemotaxis in many
immune cells. Despite extensive research into its function in numerous disorders, a thorough …

Omics technologies in allergy and asthma research: An EAACI position paper

U Radzikowska, K Baerenfaller, JA Cornejo‐Garcia… - Allergy, 2022 - Wiley Online Library
Allergic diseases and asthma are heterogenous chronic inflammatory conditions with
several distinct complex endotypes. Both environmental and genetic factors can influence …

[HTML][HTML] The epithelial barrier: The gateway to allergic, autoimmune, and metabolic diseases and chronic neuropsychiatric conditions

D Yazici, I Ogulur, Y Pat, H Babayev, E Barletta… - Seminars in …, 2023 - Elsevier
Since the 1960 s, our health has been compromised by exposure to over 350,000 newly
introduced toxic substances, contributing to the current pandemic in allergic, autoimmune …

Metabolic pathways in immune senescence and inflammaging: Novel therapeutic strategy for chronic inflammatory lung diseases. An EAACI position paper from the …

F Roth‐Walter, IM Adcock, C Benito‐Villalvilla… - Allergy, 2024 - Wiley Online Library
The accumulation of senescent cells drives inflammaging and increases morbidity of chronic
inflammatory lung diseases. Immune responses are built upon dynamic changes in cell …

Emerging roles of platelets in allergic asthma

M Yue, M Hu, F Fu, H Ruan, C Wu - Frontiers in Immunology, 2022 - frontiersin.org
Allergic asthma is a complex chronic inflammatory disease of the airways, driven by Th2
immune responses and characterized by eosinophilic pulmonary inflammation, airway …

Deciphering the role of platelets in severe allergy by an integrative omics approach

C Pablo‐Torres, E Izquierdo, TJ Tan, D Obeso… - Allergy, 2023 - Wiley Online Library
Background Mechanisms causing the onset and perpetuation of inflammation in severe
allergic patients remain unknown. Our previous studies suggested that severe allergic …

Leukocyte redistribution as immunological biomarker of corticosteroid resistance in severe asthma

C Cardoso‐Vigueros, T von Blumenthal… - Clinical & …, 2022 - Wiley Online Library
Background Earlier studies have suggested that the leukocyte redistribution can be
considered as an immunological marker of the clinical response to corticosteroids (CS) …

AllergoOncology: Biomarkers and refined classification for research in the allergy and glioma nexus—A joint EAACI‐EANO position paper

MC Turner, U Radzikowska, DE Ferastraoaru… - Allergy, 2024 - Wiley Online Library
Epidemiological studies have explored the relationship between allergic diseases and
cancer risk or prognosis in AllergoOncology. Some studies suggest an inverse association …

Transcriptomics reveals a distinct metabolic profile in T cells from severe allergic asthmatic patients

C Pablo-Torres, C Garcia-Escribano, M Romeo… - Frontiers in …, 2023 - frontiersin.org
The reasons behind the onset and continuation of chronic inflammation in individuals with
severe allergies are still not understood. Earlier findings indicated that there is a connection …