[HTML][HTML] Male infertility and oxidative stress: a focus on the underlying mechanisms
Reactive oxygen species (ROS) play a critical role in defining the functional competence of
human spermatozoa. When generated in moderate amounts, ROS promote sperm …
human spermatozoa. When generated in moderate amounts, ROS promote sperm …
[HTML][HTML] Mechanisms of mitochondrial dysfunction in lysosomal storage disorders: a review
KM Stepien, F Roncaroli, N Turton… - Journal of Clinical …, 2020 - mdpi.com
Mitochondrial dysfunction is emerging as an important contributory factor to the
pathophysiology of lysosomal storage disorders (LSDs). The cause of mitochondrial …
pathophysiology of lysosomal storage disorders (LSDs). The cause of mitochondrial …
Nanoscale covalent organic framework for combinatorial antitumor photodynamic and photothermal therapy
Q Guan, LL Zhou, YA Li, WY Li, S Wang, C Song… - ACS …, 2019 - ACS Publications
Despite the excellent photodynamic and photothermal properties of organic molecular
photosensitizers (PSs) and photothermal agents (PTAs), such as porphyrin and …
photosensitizers (PSs) and photothermal agents (PTAs), such as porphyrin and …
Hyperglycemia-driven inhibition of AMP-activated protein kinase α2 induces diabetic cardiomyopathy by promoting mitochondria-associated endoplasmic reticulum …
Background: Fundc1 (FUN14 domain containing 1), an outer mitochondrial membrane
protein, is important for mitophagy and mitochondria-associated endoplasmic reticulum …
protein, is important for mitophagy and mitochondria-associated endoplasmic reticulum …
[HTML][HTML] Ultrastructural characterization of the lower motor system in a mouse model of Krabbe disease
V Cappello, L Marchetti, P Parlanti, S Landi… - Scientific reports, 2016 - nature.com
Krabbe disease (KD) is a neurodegenerative disorder caused by the lack of β-
galactosylceramidase enzymatic activity and by widespread accumulation of the cytotoxic …
galactosylceramidase enzymatic activity and by widespread accumulation of the cytotoxic …
Mitochondrial dysfunction and neurodegeneration in lysosomal storage disorders
N Plotegher, MR Duchen - Trends in molecular medicine, 2017 - cell.com
Lysosomal storage disorders (LSDs) are rare inherited debilitating and often fatal disorders.
Caused by mutations affecting lysosomal proteins, LSDs are characterized by the …
Caused by mutations affecting lysosomal proteins, LSDs are characterized by the …
[HTML][HTML] Sphingolipid lysosomal storage diseases: from bench to bedside
M Abed Rabbo, Y Khodour, LS Kaguni… - Lipids in health and …, 2021 - Springer
Abstract Johann Ludwig Wilhelm Thudicum described sphingolipids (SLs) in the late
nineteenth century, but it was only in the past fifty years that SL research surged in …
nineteenth century, but it was only in the past fifty years that SL research surged in …
Metabolic reprogramming enables hepatocarcinoma cells to efficiently adapt and survive to a nutrient-restricted microenvironment
S Cassim, VA Raymond, L Dehbidi-Assadzadeh… - Cell cycle, 2018 - Taylor & Francis
Hepatocellular carcinoma (HCC) is a metabolically heterogeneous cancer and the use of
glucose by HCC cells could impact their tumorigenicity. Dt81Hepa1-6 cells display …
glucose by HCC cells could impact their tumorigenicity. Dt81Hepa1-6 cells display …
[HTML][HTML] Krabbe disease: New hope for an old disease
AM Bradbury, ER Bongarzone, MS Sands - Neuroscience letters, 2021 - Elsevier
Krabbe disease (globoid cell leukodystrophy) is a lysosomal storage disease (LSD)
characterized by progressive and profound demyelination. Infantile, juvenile and adult-onset …
characterized by progressive and profound demyelination. Infantile, juvenile and adult-onset …
[HTML][HTML] Lysosomal re-acidification prevents lysosphingolipid-induced lysosomal impairment and cellular toxicity
CJ Folts, N Scott-Hewitt, C Pröschel… - PLoS …, 2016 - journals.plos.org
Neurodegenerative lysosomal storage disorders (LSDs) are severe and untreatable, and
mechanisms underlying cellular dysfunction are poorly understood. We found that toxic …
mechanisms underlying cellular dysfunction are poorly understood. We found that toxic …