Reactive oxygen species (ROS) play a critical role in defining the functional competence of
human spermatozoa. When generated in moderate amounts, ROS promote sperm …

Mitochondrial dysfunction is emerging as an important contributory factor to the
pathophysiology of lysosomal storage disorders (LSDs). The cause of mitochondrial …

Despite the excellent photodynamic and photothermal properties of organic molecular
photosensitizers (PSs) and photothermal agents (PTAs), such as porphyrin and …

Background: Fundc1 (FUN14 domain containing 1), an outer mitochondrial membrane
protein, is important for mitophagy and mitochondria-associated endoplasmic reticulum …

Krabbe disease (KD) is a neurodegenerative disorder caused by the lack of β-
galactosylceramidase enzymatic activity and by widespread accumulation of the cytotoxic …

Lysosomal storage disorders (LSDs) are rare inherited debilitating and often fatal disorders.
Caused by mutations affecting lysosomal proteins, LSDs are characterized by the …

Abstract Johann Ludwig Wilhelm Thudicum described sphingolipids (SLs) in the late
nineteenth century, but it was only in the past fifty years that SL research surged in …

Hepatocellular carcinoma (HCC) is a metabolically heterogeneous cancer and the use of
glucose by HCC cells could impact their tumorigenicity. Dt81Hepa1-6 cells display …

Krabbe disease (globoid cell leukodystrophy) is a lysosomal storage disease (LSD)
characterized by progressive and profound demyelination. Infantile, juvenile and adult-onset …

Neurodegenerative lysosomal storage disorders (LSDs) are severe and untreatable, and
mechanisms underlying cellular dysfunction are poorly understood. We found that toxic …