3D cryo-electron microscopy (cryo-EM) is an expanding structural biology technique that has
recently undergone a quantum leap progression in its achievable resolution and its …

One of the most critical pathological features of Alzheimer's disease (AD) is the
accumulation of β-amyloid (Aβ) peptides that form extracellular senile plaques in the brain …

The γ-secretase complex, comprising presenilin 1 (PS1), PEN-2, APH-1 and nicastrin, is a
membrane-embedded protease that controls a number of important cellular functions …

C99 is the transmembrane carboxyl-terminal domain of the amyloid precursor protein that is
cleaved by γ-secretase to release the amyloid-β polypeptides, which are associated with …

γ-Secretase is a membrane-embedded protease complex, with presenilin as the catalytic
component containing two transmembrane aspartates in the active site. With more than 90 …

γ-Secretases are a group of widely expressed, intramembrane-cleaving proteases involved
in many physiological processes. Their clinical relevance comes from their involvement in …

The four-component intramembrane protease γ-secretase is intricately linked to the
development of Alzheimer's disease. Despite recent structural advances, the …

The 99-residue transmembrane C-terminal domain (C99, also known as β-CTF) of the
amyloid precursor protein (APP) is the product of the β-secretase cleavage of the full-length …

Alzheimer's disease (AD) is the primary cause of dementia in the elderly and one of the
major health problems worldwide. Since its first description by Alois Alzheimer in 1907 …

Alzheimer's disease (AD) is a neurodegenerative illness and the leading cause of dementia
in the elderly. The accumulation of amyloid-β peptide (Aβ) is a well-known pathological …