Cryo-EM: a unique tool for the visualization of macromolecular complexity
E Nogales, SHW Scheres - Molecular cell, 2015 - cell.com
3D cryo-electron microscopy (cryo-EM) is an expanding structural biology technique that has
recently undergone a quantum leap progression in its achievable resolution and its …
recently undergone a quantum leap progression in its achievable resolution and its …
The γ-secretase complex: from structure to function
One of the most critical pathological features of Alzheimer's disease (AD) is the
accumulation of β-amyloid (Aβ) peptides that form extracellular senile plaques in the brain …
accumulation of β-amyloid (Aβ) peptides that form extracellular senile plaques in the brain …
Three-dimensional structure of human γ-secretase
The γ-secretase complex, comprising presenilin 1 (PS1), PEN-2, APH-1 and nicastrin, is a
membrane-embedded protease that controls a number of important cellular functions …
membrane-embedded protease that controls a number of important cellular functions …
The amyloid precursor protein has a flexible transmembrane domain and binds cholesterol
PJ Barrett, Y Song, WD Van Horn, EJ Hustedt… - Science, 2012 - science.org
C99 is the transmembrane carboxyl-terminal domain of the amyloid precursor protein that is
cleaved by γ-secretase to release the amyloid-β polypeptides, which are associated with …
cleaved by γ-secretase to release the amyloid-β polypeptides, which are associated with …
Structure and Function of the γ-Secretase Complex
MS Wolfe - Biochemistry, 2019 - ACS Publications
γ-Secretase is a membrane-embedded protease complex, with presenilin as the catalytic
component containing two transmembrane aspartates in the active site. With more than 90 …
component containing two transmembrane aspartates in the active site. With more than 90 …
Learning by failing: ideas and concepts to tackle γ-secretases in Alzheimer's disease and beyond
B De Strooper… - Annual review of …, 2015 - annualreviews.org
γ-Secretases are a group of widely expressed, intramembrane-cleaving proteases involved
in many physiological processes. Their clinical relevance comes from their involvement in …
in many physiological processes. Their clinical relevance comes from their involvement in …
Structural basis of human γ-secretase assembly
L Sun, L Zhao, G Yang, C Yan… - Proceedings of the …, 2015 - National Acad Sciences
The four-component intramembrane protease γ-secretase is intricately linked to the
development of Alzheimer's disease. Despite recent structural advances, the …
development of Alzheimer's disease. Despite recent structural advances, the …
Competition between homodimerization and cholesterol binding to the C99 domain of the amyloid precursor protein
Y Song, EJ Hustedt, S Brandon, CR Sanders - Biochemistry, 2013 - ACS Publications
The 99-residue transmembrane C-terminal domain (C99, also known as β-CTF) of the
amyloid precursor protein (APP) is the product of the β-secretase cleavage of the full-length …
amyloid precursor protein (APP) is the product of the β-secretase cleavage of the full-length …
Alzheimer culprits: cellular crossroads and interplay
S Claeysen, M Cochet, R Donneger, A Dumuis… - Cellular signalling, 2012 - Elsevier
Alzheimer's disease (AD) is the primary cause of dementia in the elderly and one of the
major health problems worldwide. Since its first description by Alois Alzheimer in 1907 …
major health problems worldwide. Since its first description by Alois Alzheimer in 1907 …
Nuclear signalling by membrane protein intracellular domains: the AICD enigma
C Beckett, NN Nalivaeva, ND Belyaev, AJ Turner - Cellular signalling, 2012 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative illness and the leading cause of dementia
in the elderly. The accumulation of amyloid-β peptide (Aβ) is a well-known pathological …
in the elderly. The accumulation of amyloid-β peptide (Aβ) is a well-known pathological …