The CB 1 and CB 2 cannabinoid receptors (CB 1 R, CB 2 R) are members of the G protein-
coupled receptor (GPCR) family that were identified over 20 years ago. CB 1 Rs and CB 2 …

Neuropsychiatric disorders are multifactorial disorders with diverse aetiological factors.
Identifying treatment targets is challenging because the diseases are resulting from …

Bidirectional communication between neurons and astrocytes shapes synaptic plasticity and
behavior. D-serine is a necessary co-agonist of synaptic N-methyl-D-aspartate receptors …

The endocannabinoid system, which includes cannabinoid receptor 1 and 2 subtypes
(CB1R and CB2R, respectively), is responsible for the onset of various pathologies including …

Cannabidiol (CBD), the major non-psychotomimetic compound present in the Cannabis
sativa plant, exhibits therapeutic potential for various human diseases, including chronic …

The generation of functional regulatory T cells (Tregs) is essential to keep tissue
homeostasis and restore healthy immune responses in many biological and inflammatory …

Since antiquity, Cannabis has provoked enormous intrigue for its potential medicinal
properties as well as for its unique pharmacological effects. The elucidation of its major …

Recent evidence has raised in discussion the possibility that cannabidiol can act as a
negative allosteric modulator of the cannabinoid type 1 receptor. Here we have used …

A deep convolutional generative adversarial network (dcGAN) model was developed in this
study to screen and design target-specific novel compounds for cannabinoid receptors. In …

The cannabinoid 1 receptor (CB1R) is one of the most widely expressed metabotropic G
protein-coupled receptors in brain, and its participation in various (patho) physiological …