[HTML][HTML] Emergence and adaptation of the cellular machinery directing antigenic variation in the African trypanosome
Survival of the African trypanosome within its mammalian hosts, and hence transmission
between hosts, relies upon antigenic variation, where stochastic changes in the composition …
between hosts, relies upon antigenic variation, where stochastic changes in the composition …
Living organisms author their read-write genomes in evolution
JA Shapiro - Biology, 2017 - mdpi.com
Evolutionary variations generating phenotypic adaptations and novel taxa resulted from
complex cellular activities altering genome content and expression:(i) Symbiogenetic cell …
complex cellular activities altering genome content and expression:(i) Symbiogenetic cell …
Profiling the bloodstream form and procyclic form Trypanosoma brucei cell cycle using single-cell transcriptomics
African trypanosomes proliferate as bloodstream forms (BSFs) and procyclic forms in the
mammal and tsetse fly midgut, respectively. This allows them to colonise the host …
mammal and tsetse fly midgut, respectively. This allows them to colonise the host …
Changing of the guard: How the Lyme disease spirochete subverts the host immune response
G Chaconas, M Castellanos, TB Verhey - Journal of Biological Chemistry, 2020 - ASBMB
Lyme disease, also known as Lyme borreliosis, is the most common tick-transmitted disease
in the Northern Hemisphere. The disease is caused by the bacterial spirochete Borrelia …
in the Northern Hemisphere. The disease is caused by the bacterial spirochete Borrelia …
G-quadruplex identification in the genome of protozoan parasites points to naphthalene diimide ligands as new antiparasitic agents
E Belmonte-Reche, M Martínez-García… - Journal of Medicinal …, 2018 - ACS Publications
G-quadruplexes (G4) are DNA secondary structures that take part in the regulation of gene
expression. Putative G4 forming sequences (PQS) have been reported in mammals, yeast …
expression. Putative G4 forming sequences (PQS) have been reported in mammals, yeast …
RAD51-mediated R-loop formation acts to repair transcription-associated DNA breaks driving antigenic variation in Trypanosoma brucei
MJ Girasol, M Krasilnikova… - Proceedings of the …, 2023 - National Acad Sciences
RNA–DNA hybrids are epigenetic features of all genomes that intersect with many
processes, including transcription, telomere homeostasis, and centromere function …
processes, including transcription, telomere homeostasis, and centromere function …
Initiation of homologous recombination at DNA nicks
N Maizels, L Davis - Nucleic acids research, 2018 - academic.oup.com
Discontinuities in only a single strand of the DNA duplex occur frequently, as a result of DNA
damage or as intermediates in essential nuclear processes and DNA repair. Nicks are the …
damage or as intermediates in essential nuclear processes and DNA repair. Nicks are the …
Ribonuclease H1-targeted R-loops in surface antigen gene expression sites can direct trypanosome immune evasion
Switching of the Variant Surface Glycoprotein (VSG) in Trypanosoma brucei provides a
crucial host immune evasion strategy that is catalysed both by transcription and …
crucial host immune evasion strategy that is catalysed both by transcription and …
Trypanosoma brucei ribonuclease H2A is an essential R-loop processing enzyme whose loss causes DNA damage during transcription initiation and antigenic …
Ribonucleotides represent a threat to DNA genome stability and transmission. Two types of
Ribonuclease H (RNase H) excise ribonucleotides when they form part of the DNA strand, or …
Ribonuclease H (RNase H) excise ribonucleotides when they form part of the DNA strand, or …
Emerging challenges in understanding trypanosome antigenic variation
Many pathogens evade host immunity by periodically changing the proteins they express on
their surface—a phenomenon termed antigenic variation. An extreme form of antigenic …
their surface—a phenomenon termed antigenic variation. An extreme form of antigenic …