Major recent advances and previous data have led to a plausible model of how key proteins
mediate neurotransmitter release. In this model, the soluble N-ethylmaleimide-sensitive …

Membrane fusion is a key process in all living organisms that contributes to a variety of
biological processes including viral infection, cell fertilization, as well as intracellular …

Munc18-1 forms a template to organize assembly of the neuronal SNARE complex that
triggers neurotransmitter release, binding first to a closed conformation of syntaxin-1 where …

SNARE proteins and Sec1/Munc18 (SM) proteins constitute the core molecular engine that
drives nearly all intracellular membrane fusion and exocytosis. While SNAREs are known to …

Extensive research has yielded crucial insights into the mechanism of neurotransmitter
release, and working models for the functions of key proteins involved in release. The …

Research for three decades and major recent advances have provided crucial insights into
how neurotransmitters are released by Ca2+‐triggered synaptic vesicle exocytosis, leading …

Synaptic vesicles are primed into a state that is ready for fast neurotransmitter release upon
Ca 2+-binding to Synaptotagmin-1. This state likely includes trans-SNARE complexes …

Intracellular membrane fusion is mediated in most cases by membrane-bridging complexes
of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) …

Fusion of intracellular transport vesicles requires soluble N-ethylmaleimide–sensitive factor
attachment protein receptors (SNAREs) and Sec1/Munc18-family (SM) proteins. Membrane …

Sec1/Munc18-family (SM) proteins are required for SNARE-mediated membrane fusion, but
their mechanism (s) of action remain controversial. Using single-molecule force …