A number of syndromic disorders have renal cysts as a component of their phenotypes.
These disorders can generally be distinguished from autosomal dominant polycystic kidney …

Ciliopathies are a group of clinically and genetically overlapping disorders whose etiologies
lie in defective cilia. These are antenna-like organelles on the apical surface of numerous …

Background In autosomal dominant polycystic kidney disease (ADPKD), aberrant activation
of the mammalian target of rapamycin (mTOR) pathway is associated with progressive …

Activation of mammalian target of rapamycin (mTOR) pathways may contribute to
uncontrolled cell proliferation and secondary cyst growth in patients with autosomal …

Mammalian target of rapamycin (mTOR) is the core component of two complexes, mTORC1
and mTORC2. mTORC1 is inhibited by rapamycin and analogues. mTORC2 is impeded …

Background. Activation of the mTOR pathway has been implicated in the mediation of the
progression of polycystic kidney disease (PKD). Whereas targeted inhibition of mTOR has …

Mammalian target of rapamycin (mTOR) inhibitors (mTORis) constitute a relatively new
category of immunosuppressive and antineoplastic drugs. These share a unique …

Background Autosomal dominant polycystic kidney disease (ADPKD) is the most common
inherited disorder causing kidney disease. Current clinical management of ADPKD focuses …

Importance of the field: Autosomal dominant (AD) polycystic kidney disease (PKD) is the
most common life-threatening hereditary disorder. There is currently no therapy that slows or …

Introduction Autosomal dominant polycystic kidney disease (ADPKD) is a progressive
genetic kidney disease. Studies of ADPKD presented results using different outcome …