Synthesis strategies and medicinal value of pyrrole and its fused heterocyclic compounds

SS Fatahala, MS Mohamed, JY Sabry… - Medicinal …, 2022 - benthamdirect.com
In the last several decades, interest in pyrrole and pyrrolopyrimidine derivatives has
increased owing to their biological importance, such as anti-tumor, anti-microbial, anti …

Pyrrole: An Essential Framework in the Development of Therapeutic Agents and Insightful Analysis of Structure‐Active Relationships

B Sahu, R Sahu, B Gidwani, A Mishra - ChemistrySelect, 2024 - Wiley Online Library
Pyrrole is a heterocyclic structure with diverse pharmacophores, enabling the creation of an
extensive lead molecule library. Its broad range of pharmacological profiles has concerned …

In vitro and in silico exploration of newly synthesized triazolyl- isonicotinohydrazides as potent antitubercular agents

RD Bakale, PS Phatak, SS Rathod… - Journal of …, 2023 - Taylor & Francis
In the present study, we have reported the synthesis of novel isoniazid-triazole derivatives
(4a-r), via the click chemistry approach. The synthesized isoniazid-triazole derivatives have …

A new series of asymmetric bis-isatin derivatives containing urea/thiourea moiety: Preparation, spectroscopic elucidation, antioxidant properties and theoretical …

H Yakan, MS Cavuş, BZ Kurt, H Muğlu… - Journal of Molecular …, 2021 - Elsevier
In the present study, design, synthesis, characterization, and investigation of antioxidant
properties of novel asymmetric bis-isatin derivatives (1-8) containing urea/thiourea moiety …

Screening of potent α‐glucosidase inhibitory and antioxidant polyphenols in Prunella vulgaris L. by bioreaction–HPLC–quadrupole‐time‐of‐flight‐MS/MS and in …

L Cheng, F Wang, Y Cao, G Cai, Q Wei… - Journal of …, 2022 - Wiley Online Library
Prunella vulgaris L. is a well‐known traditional Chinese medicine for blood glucose
homeostasis and antioxidant potential. Ethyl acetate fraction of P. vulgaris L. demonstrated …

Relationship between antioxidant activity and ESIPT process based on flavonoid derivatives: A comprehensive analysis

X Tang, L Wang, Y Zhang, C Sun - … Acta Part A: Molecular and Biomolecular …, 2025 - Elsevier
Antioxidant activity, as a topic of current interest, is discussed together with the excited state
intramolecular proton transfer (ESIPT) process for three flavonoid derivatives, based on …

Activation of xanthine oxidase by 1, 4-naphthoquinones: A novel potential research topic for diet management and risk assessment

S Liang, L Liu, B He, W Zhao, W Zhang, L Xiao… - Food Chemistry, 2023 - Elsevier
Abstract Oral intake of 1, 4-naphthoquinones could be a potential risk factor for
hyperuricemia and gout via activation of xanthine oxidase (XO). Herein, 1, 4 …

Structure–antioxidant activity relationships of dendrocandin analogues determined using density functional theory

N Zhang, Y Wu, M Qiao, W Yuan, X Li, X Wang… - Structural Chemistry, 2022 - Springer
Quantum-chemical calculations based on the density functional theory (DFT) at the B3LYP/6–
311++ G (2d, 2p)//B3LYP/6–31G (d, p) level were employed to study the relationship …

Clauson–Kaas pyrrole synthesis using diverse catalysts: a transition from conventional to greener approach

DK Singh, R Kumar - Beilstein Journal of Organic Chemistry, 2023 - beilstein-journals.org
Pyrrole is an important aromatic heterocyclic scaffold found in many natural products and
predominantly used in pharmaceuticals. Continuous efforts are being made to design and …

[HTML][HTML] Multi-component synthesis and invitro biological assessment of novel pyrrole derivatives and pyrano[2,3-c]pyrazole derivatives using Co3O4 nanoparticles …

TM Almeleebia, M Jasim Naser, SM Saeed… - Frontiers in …, 2024 - frontiersin.org
In this study, Co3O4 nanoparticles were used as nanocatalyst for two different series of
nitrogen-containing heterocyclic compounds, including pyrrole (Pyo) derivatives and pyrano …