Bacterial terpenome

JD Rudolf, TA Alsup, B Xu, Z Li - Natural product reports, 2021 - pubs.rsc.org
Covering: up to mid-2020 Terpenoids, also called isoprenoids, are the largest and most
structurally diverse family of natural products. Found in all domains of life, there are over 80 …

Review on plant terpenoid emissions worldwide and in China

W Yang, J Cao, Y Wu, F Kong, L Li - Science of the Total Environment, 2021 - Elsevier
Biogenic volatile organic compounds (BVOCs), particularly terpenoids, can significantly
drive the formation of ozone (O 3) and secondary organic aerosols (SOA) in the atmosphere …

Catalytic role of carbonyl oxygens and water in selinadiene synthase

YH Wang, H Xu, J Zou, XB Chen, YQ Zhuang, WL Liu… - Nature …, 2022 - nature.com
Terpene synthases (TSs) catalyse the most complex cyclization cascades in nature, with
generation and taming of reactive carbocations. Although deprotonation–reprotonation …

Mechanistic investigations of two bacterial diterpene cyclases: spiroviolene synthase and tsukubadiene synthase

P Rabe, J Rinkel, E Dolja, T Schmitz… - Angewandte Chemie …, 2017 - Wiley Online Library
The mechanisms of two diterpene cyclases from streptomycetes—one with an unknown
product that was identified as the spirocyclic hydrocarbon spiroviolene and one with the …

Genome-based discovery of an unprecedented cyclization mode in fungal sesterterpenoid biosynthesis

M Okada, Y Matsuda, T Mitsuhashi… - Journal of the …, 2016 - ACS Publications
Sesterterpenoids are a group of terpenoid natural products that are primarily biosynthesized
via cyclization of the C25 linear substrate geranylfarnesyl pyrophosphate (GFPP). Although …

Mechanistic Characterization of Two Chimeric Sesterterpene Synthases from Penicillium

T Mitsuhashi, J Rinkel, M Okada, I Abe… - … A European Journal, 2017 - Wiley Online Library
The products of two bifunctional fungal sesterterpene synthases (StTPS), with prenyl
transferase (PT) and terpene synthase (TPS) domains from Penicillium, were structurally …

Exploiting the synthetic potential of sesquiterpene cyclases for generating unnatural terpenoids

C Oberhauser, V Harms, K Seidel… - Angewandte Chemie …, 2018 - Wiley Online Library
The substrate flexibility of eight purified sesquiterpene cyclases was evaluated using six
new heteroatom‐modified farnesyl pyrophosphates, and the formation of six new …

Germacrene A–A central intermediate in sesquiterpene biosynthesis

H Xu, JS Dickschat - Chemistry–A European Journal, 2020 - Wiley Online Library
This review summarises known sesquiterpenes whose biosyntheses proceed through the
intermediate germacrene A. First, the occurrence and biosynthesis of germacrene A in …

A Clade II‐D Fungal Chimeric Diterpene Synthase from Colletotrichum gloeosporioides Produces Dolasta‐1(15),8‐diene

G Bian, J Rinkel, Z Wang, L Lauterbach… - Angewandte Chemie …, 2018 - Wiley Online Library
Based on a terpenoid overproduction platform in yeast for genome mining, a chimeric
diterpene synthase from the endophytic fungus Colletotrichum gloeosporioides ES026 was …

Terpene cyclases from social amoebae

P Rabe, J Rinkel, B Nubbemeyer… - Angewandte Chemie …, 2016 - Wiley Online Library
Genome sequences of social amoebae reveal the presence of terpene cyclases (TCs) in
these organisms. Two TCs from Dictyostelium discoideum converted farnesyl diphosphate …