Converting nanotoxicity data to information using artificial intelligence and simulation

X Yan, T Yue, DA Winkler, Y Yin, H Zhu… - Chemical …, 2023 - ACS Publications
Decades of nanotoxicology research have generated extensive and diverse data sets.
However, data is not equal to information. The question is how to extract critical information …

Advancing computational toxicology by interpretable machine learning

X Jia, T Wang, H Zhu - Environmental Science & Technology, 2023 - ACS Publications
Chemical toxicity evaluations for drugs, consumer products, and environmental chemicals
have a critical impact on human health. Traditional animal models to evaluate chemical …

Advancing computational toxicology in the big data era by artificial intelligence: data-driven and mechanism-driven modeling for chemical toxicity

HL Ciallella, H Zhu - Chemical research in toxicology, 2019 - ACS Publications
In 2016, the Frank R. Lautenberg Chemical Safety for the 21st Century Act became the first
US legislation to advance chemical safety evaluations by utilizing novel testing approaches …

IVIVE: Facilitating the Use of In Vitro Toxicity Data in Risk Assessment and Decision Making

X Chang, YM Tan, DG Allen, S Bell, PC Brown… - Toxics, 2022 - mdpi.com
During the past few decades, the science of toxicology has been undergoing a
transformation from observational to predictive science. New approach methodologies …

In silico prediction of toxicity and its applications for chemicals at work

KT Rim - Toxicology and environmental health sciences, 2020 - Springer
Objective and methods This study reviewed the concept of in silico prediction of chemical
toxicity for prevention of occupational cancer and future prospects in workers' health. In this …

In vitro Alternatives to Acute Inhalation Toxicity Studies in Animal Models—A Perspective

D Movia, S Bruni-Favier, A Prina-Mello - Frontiers in bioengineering …, 2020 - frontiersin.org
When assessing the risk and hazard of a non-pharmaceutical compound, the first step is
determining acute toxicity, including toxicity following inhalation. Inhalation is a major …

Use of EpiAlveolar lung model to predict fibrotic potential of multiwalled carbon nanotubes

H Barosova, AG Maione, D Septiadi, M Sharma… - Acs Nano, 2020 - ACS Publications
Expansion in production and commercial use of nanomaterials increases the potential
human exposure during the lifecycle of these materials (production, use, and disposal) …

Emerging technologies for in vitro inhalation toxicology

AV Singh, A Romeo, K Scott, S Wagener… - Advanced …, 2021 - Wiley Online Library
Respiratory toxicology remains a major research area in the 21st century since current
scenario of airborne viral infection transmission and pollutant inhalation is expected to raise …

New approach methods to evaluate health risks of air pollutants: Critical design considerations for in vitro exposure testing

J Zavala, AN Freedman, JT Szilagyi, I Jaspers… - International journal of …, 2020 - mdpi.com
Air pollution consists of highly variable and complex mixtures recognized as major
contributors to morbidity and mortality worldwide. The vast number of chemicals, coupled …

Applications of the 12 principles of green chemistry in the crop protection industry

GT Whiteker - Organic Process Research & Development, 2019 - ACS Publications
This review discusses specific examples of the application of the 12 principles of green
chemistry from the crop protection industry. Many of the examples are operated on a multiton …