Sepsis is a life-threatening condition and a global disease burden. Today, the
heterogeneous syndrome is defined as severe organ dysfunction caused by a dysregulated …

The peripheral arterial vasodilation hypothesis has been most influential in the field of
cirrhosis and its complications. It has given rise to hundreds of pathophysiological studies in …

Sepsis and sepsis-associated multi-organ failure are major challenges for scientists and
clinicians and are a tremendous burden for health-care systems. Despite extensive basic …

The anaphylatoxin (AT) C3a, C5a and C5a-desArg are generally considered pro-
inflammatory polypeptides generated after proteolytic cleavage of C3 and C5 in response to …

Sepsis remains a critical problem with significant morbidity and mortality even in the modern
era of critical care management. Multiple derangements exist in sepsis involving several …

Myocardial dysfunction is one of the main predictors of poor outcome in septic patients, with
mortality rates next to 70%. During the sepsis-induced myocardial dysfunction, both …

Sepsis, a medical emergency, is the overwhelming host response to infection leading to
organ failure. The pathophysiology of this heterogeneous disease includes an inflammatory …

Complement fragment (C) 5a is a 74 residue pro‐inflammatory polypeptide produced during
activation of the complement cascade of serum proteins in response to foreign surfaces such …

Clinical and technological advances promoting early hemorrhage control and physiologic
resuscitation as well as early diagnosis and optimal treatment of sepsis have significantly …

Sepsis is a leading cause of intensive care unit admission and death worldwide. Most
surviving patients show acute or chronic mental disorders, which are known as sepsis …