Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …

After nuclear factor (NF)-κB activation, a complex network of negative feedback loops
ensures that the termination of the NF-κB response occurs in a highly organized manner …

The unique permselectivity of cellular membranes is of crucial importance to maintain
intracellular homeostasis while adapting to microenvironmental changes. Although …

In zebrafish, retinal injury stimulates Müller glia (MG) reprograming, allowing them to
generate multipotent progenitors that replace damaged cells and restore vision. Recent …

Rhythmic and sequential subdivision of the elongating vertebrate embryonic body axis into
morphological somites is controlled by an oscillating multicellular genetic network termed …

The fundamental mechanisms that control and regulate biological organisms exhibit a
surprising level of complexity. Oscillators are perhaps the simplest motifs that produce time …

Despite the sequencing of the human genome, the rate of innovative and successful drug
discovery in the pharmaceutical industry has continued to decrease. Leaving aside …

Circadian clocks have long been known to be essential for the maintenance of physiological
and behavioral processes in a variety of organisms ranging from plants to humans …

Background In individual living cells p53 has been found to be expressed in a series of
discrete pulses after DNA damage. Its negative regulator Mdm2 also demonstrates …

The function of living cells is controlled by complex regulatory networks that are built of a
wide diversity of interacting molecular components. The sheer size and intricacy of …