Simple Summary The molecular mechanisms of Charcot–Marie–Tooth (CMT) disease,
involving impaired vitamin metabolism and/or actions, are considered in light of the potential …

The α-keto acid dehydrogenase complex (KDHc) class of mitochondrial enzymes is
composed of four members: pyruvate dehydrogenase (PDHc), α-ketoglutarate …

Amino acid deprivation therapy (AADT) is a promising strategy for developing novel
anticancer treatments, based on variations in metabolism of healthy and malignant cells. L …

Abnormal energy expenditure during seizures and metabolic regulation through post-
translational protein acylation suggest acylation as a therapeutic target in epilepsy. Our goal …

Organism adaptation to metabolic challenges requires coupling of metabolism to gene
expression. In this regard, acylations of histones and metabolic proteins acquire significant …

Introducing personalized therapies requires a better, than implemented currently, coupling
of basic research to medicine. The current topic is dedicated to promote this coupling …

The present work delves into the enigmatic world of mitochondrial alpha-keto acid
dehydrogenase complexes discussing their metabolic significance, enzymatic operation …

This study aimed to explore diagnostic biomarkers associated with mitochondria in the
treatment of diabetic nephropathy (DN) using Rhodiola Rosea (RR) and to elucidate the …

Adaptation of an organism to metabolic challenges requires mechanisms coupling
metabolism to gene expression. Acylations of metabolic and histone proteins acquire …

Understanding molecular mechanisms of neurological disorders is required for development
of personalized medicine. When the diagnosis considers not only the disease symptoms, but …