Short-chain fatty acids (SCFAs), particularly acetate, propionate and butyrate, are mainly
produced by anaerobic fermentation of gut microbes. SCFAs play an important role in …

Since the discovery of AMP-activated protein kinase (AMPK) as a central regulator of energy
homeostasis, many exciting insights into its structure, regulation and physiological roles …

Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) remain
without effective therapies. The mechanistic target of rapamycin complex 1 (mTORC1) …

Transcriptional regulation of catabolic pathways is a central mechanism by which cells
respond to physiological cues to generate the energy required for anabolic pathways …

The AMP-activated protein kinase (AMPK) is a central regulator of multiple metabolic
pathways and may have therapeutic importance for treating obesity, insulin resistance, type …

TOR (target of rapamycin), an evolutionarily-conserved serine/threonine kinase, acts as a
central regulator of cell growth, proliferation and survival in response to nutritional status …

This study compares the effect of two types of exercise training, ie, moderate-intensity
continuous training (MICT) or high-intensity interval training (HIIT) on the browning of …

Increased macroautophagy/autophagy and lysosomal activity promote tumor growth,
survival and chemo-resistance. During acute starvation, autophagy is rapidly engaged by …

Stimulation of adipose tissue thermogenesis is regarded as a promising avenue in the
treatment of obesity. However, pharmacologic engagement of this process has proven …

Abstract Purpose of Review The global prevalence of type 2 diabetes (T2D) is escalating at
alarming rates, demanding the development of additional classes of therapeutics to further …