Recent advances in osteoclast biology
T Ono, T Nakashima - Histochemistry and cell biology, 2018 - Springer
The bone is an essential organ for locomotion and protection of the body, as well as
hematopoiesis and mineral homeostasis. In order to exert these functions throughout life …
hematopoiesis and mineral homeostasis. In order to exert these functions throughout life …
[HTML][HTML] Coupling the activities of bone formation and resorption: a multitude of signals within the basic multicellular unit
NA Sims, TJ Martin - BoneKEy reports, 2014 - ncbi.nlm.nih.gov
Coupling between bone formation and bone resorption refers to the process within basic
multicellular units in which resorption by osteoclasts is met by the generation of osteoblasts …
multicellular units in which resorption by osteoclasts is met by the generation of osteoblasts …
[HTML][HTML] Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption
Osteoclasts are large multinucleated bone-resorbing cells formed by the fusion of monocyte/
macrophage-derived precursors that are thought to undergo apoptosis once resorption is …
macrophage-derived precursors that are thought to undergo apoptosis once resorption is …
Sphingosine-1-phosphate signaling and its role in disease
M Maceyka, KB Harikumar, S Milstien, S Spiegel - Trends in cell biology, 2012 - cell.com
The bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P) is now recognized as
a critical regulator of many physiological and pathophysiological processes, including …
a critical regulator of many physiological and pathophysiological processes, including …
Osteoclasts: more than 'bone eaters'
JF Charles, AO Aliprantis - Trends in molecular medicine, 2014 - cell.com
As the only cells definitively shown to degrade bone, osteoclasts are key mediators of
skeletal diseases including osteoporosis. Bone-forming osteoblasts, and hematopoietic and …
skeletal diseases including osteoporosis. Bone-forming osteoblasts, and hematopoietic and …
Osteoblast-derived vesicles induce a switch from bone-formation to bone-resorption in vivo
M Uenaka, E Yamashita, J Kikuta, A Morimoto… - Nature …, 2022 - nature.com
Bone metabolism is regulated by the cooperative activity between bone-forming osteoblasts
and bone-resorbing osteoclasts. However, the mechanisms mediating the switch between …
and bone-resorbing osteoclasts. However, the mechanisms mediating the switch between …
Cathepsin K inhibitors for osteoporosis: biology, potential clinical utility, and lessons learned
MT Drake, BL Clarke, MJ Oursler, S Khosla - Endocrine reviews, 2017 - academic.oup.com
Cathepsin K is a cysteine protease member of the cathepsin lysosomal protease family.
Although cathepsin K is highly expressed in osteoclasts, lower levels of cathepsin K are also …
Although cathepsin K is highly expressed in osteoclasts, lower levels of cathepsin K are also …
Sphingosine-1-phosphate and lymphocyte egress from lymphoid organs
JG Cyster, SR Schwab - Annual review of immunology, 2012 - annualreviews.org
Much has been learned about how cells enter lymphoid tissues. But how do they leave?
Sphingosine-1-phosphate (S1P) has emerged over the past decade as a central mediator of …
Sphingosine-1-phosphate (S1P) has emerged over the past decade as a central mediator of …
Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond
GT Kunkel, M Maceyka, S Milstien… - Nature reviews Drug …, 2013 - nature.com
The bioactive lipid sphingosine-1-phosphate (S1P) is involved in multiple cellular signalling
systems and has a pivotal role in the control of immune cell trafficking. As such, S1P has …
systems and has a pivotal role in the control of immune cell trafficking. As such, S1P has …
Osteoclasts provide coupling signals to osteoblast lineage cells through multiple mechanisms
NA Sims, TJ Martin - Annual review of physiology, 2020 - annualreviews.org
Bone remodeling is essential for the repair and replacement of damaged and old bone. The
major principle underlying this process is that osteoclast-mediated resorption of a quantum …
major principle underlying this process is that osteoclast-mediated resorption of a quantum …