Sequence variants in gene regulatory regions alter gene expression and contribute to
phenotypes of individual cells and the whole organism, including disease susceptibility and …

In the analysis of omics data, integrative analysis provides an effective way of pooling
information across multiple datasets or multiple correlated responses, and can be more …

In the postgenome era, multiple types of molecular data for the same set of samples are
often available and should be analyzed jointly in an integrative analysis in order to maximize …

Allele-specific measurements of transcription factor binding from ChIP-seq data are key to
dissecting the allelic effects of non-coding variants and their contribution to phenotypic …

Abstract Several Genome Wide Association Studies (GWAS) have reported variants
associated to immune diseases. However, the identified variants are rarely the drivers of the …

DNA barcodes enable Oxford Nanopore sequencing to sequence multiple barcoded DNA
samples on a single flow cell. DNA sequences with the same barcode need to be grouped …

Genome-wide association studies (GWAS) point to regions with associated genetic variants
but rarely to a specific gene and therefore detailed knowledge regarding the genes …

Abstract Motivation: Chromatin immunoprecipitation (ChIP) followed by high-throughput
sequencing (ChIP-Seq) measures the genome-wide occupancy of transcription factors in …

Genetic variation has long been known to alter transcription factor binding sites, resulting in
sometimes major phenotypic consequences. While the performance for current binding site …

The assessment of expression and epigenomic status using sequencing based methods
provides an unprecedented opportunity to identify and correlate allelic differences with …