MRI in neuromuscular diseases: an emerging diagnostic tool and biomarker for prognosis and efficacy

JR Dahlqvist, P Widholm, OD Leinhard… - Annals of …, 2020 - Wiley Online Library
There is an unmet need to identify biomarkers sensitive to change in rare, slowly
progressive neuromuscular diseases. Quantitative magnetic resonance imaging (MRI) of …

[HTML][HTML] Magnetic resonance imaging techniques for the quantitative analysis of skeletal muscle: state of the art

K Engelke, O Chaudry, L Gast, MAB Eldib… - Journal of Orthopaedic …, 2023 - Elsevier
Background Magnetic resonance imaging (MRI) is the dominant 3D imaging modality to
quantify muscle properties in skeletal muscle disorders, in inherited and acquired muscle …

Linearity and bias of proton density fat fraction as a quantitative imaging biomarker: a multicenter, multiplatform, multivendor phantom study

HH Hu, T Yokoo, MR Bashir, CB Sirlin, D Hernando… - Radiology, 2021 - pubs.rsna.org
Background Proton density fat fraction (PDFF) estimated by using chemical shift–encoded
(CSE) MRI is an accepted imaging biomarker of hepatic steatosis. This work aims to promote …

The effect of ageing on skeletal muscle as assessed by quantitative MR imaging: an association with frailty and muscle strength

M Farrow, J Biglands, SF Tanner, A Clegg… - Aging clinical and …, 2021 - Springer
Background Skeletal muscles undergo changes with ageing which can cause sarcopenia
that can result in frailty. Quantitative MRI may detect the muscle-deficit component of frailty …

Quantitative MRI of skeletal muscle in a cross‐sectional cohort of patients with spinal muscular atrophy types 2 and 3

LAM Otto, WL van der Pol, L Schlaffke… - NMR in …, 2020 - Wiley Online Library
The aim of this study was to document upper leg involvement in spinal muscular atrophy
(SMA) with quantitative MRI (qMRI) in a cross‐sectional cohort of patients of varying type …

Muscle Steatosis and Fibrosis in Older Adults, From the AJR Special Series on Imaging of Fibrosis

L Lenchik, V Mazzoli, PM Cawthon… - American Journal of …, 2024 - ajronline.org
The purpose of this article is to review steatosis and fibrosis of skeletal muscle, focusing on
older adults. Although CT, MRI, and ultrasound are commonly used to image skeletal …

[HTML][HTML] MRI in the assessment of adipose tissues and muscle composition: how to use it

FA Huber, F Del Grande, S Rizzo… - … imaging in medicine …, 2020 - ncbi.nlm.nih.gov
Body composition analysis based on the characterization of different tissue compartments is
currently experiencing increasing attention by a broad range of medical disciplines for both …

Quantitative muscle MRI captures early muscle degeneration in calpainopathy

J Forsting, M Rohm, M Froeling, AK Güttsches… - Scientific reports, 2022 - nature.com
To evaluate differences in qMRI parameters of muscle diffusion tensor imaging (mDTI), fat-
fraction (FF) and water T2 time in leg muscles of calpainopathy patients (LGMD R1/D4) …

Selection approach to identify the optimal biomarker using quantitative muscle MRI and functional assessments in Becker muscular dystrophy

NM van de Velde, MT Hooijmans… - Neurology, 2021 - AAN Enterprises
Objective To identify the best quantitative fat–water MRI biomarker for disease progression
of leg muscles in Becker muscular dystrophy (BMD) by applying a stepwise approach based …

The feasibility of quantitative MRI of extra‐ocular muscles in myasthenia gravis and Graves' orbitopathy

KR Keene, L van Vught, NM van de Velde… - NMR in …, 2021 - Wiley Online Library
Although quantitative MRI can be instrumental in the diagnosis and assessment of disease
progression in orbital diseases involving the extra‐ocular muscles (EOM), acquisition can be …