Advances in CLIP technologies for studies of protein-RNA interactions
RNA binding proteins (RBPs) regulate all aspects in the life cycle of RNA molecules. To
elucidate the elements that guide RNA specificity, regulatory mechanisms, and functions of …
elucidate the elements that guide RNA specificity, regulatory mechanisms, and functions of …
[HTML][HTML] Serine/arginine-rich splicing factors: the bridge linking alternative splicing and cancer
X Zheng, Q Peng, L Wang, X Zhang… - … journal of biological …, 2020 - ncbi.nlm.nih.gov
The serine/arginine-rich splicing factors (SRs) belong to the serine arginine-rich protein
family, which plays an extremely important role in the splicing process of precursor RNA …
family, which plays an extremely important role in the splicing process of precursor RNA …
Sequence, structure, and context preferences of human RNA binding proteins
D Dominguez, P Freese, MS Alexis, A Su, M Hochman… - Molecular cell, 2018 - cell.com
RNA binding proteins (RBPs) orchestrate the production, processing, and function of
mRNAs. Here, we present the affinity landscapes of 78 human RBPs using an unbiased …
mRNAs. Here, we present the affinity landscapes of 78 human RBPs using an unbiased …
Differential functions of splicing factors in mammary transformation and breast cancer metastasis
Misregulation of alternative splicing is a hallmark of human tumors, yet to what extent and
how it contributes to malignancy are only beginning to be unraveled. Here, we define which …
how it contributes to malignancy are only beginning to be unraveled. Here, we define which …
The Foundational Data Initiative for Parkinson Disease: Enabling efficient translation from genetic maps to mechanism
Summary The Foundational Data Initiative for Parkinson Disease (FOUNDIN-PD) is an
international collaboration producing fundamental resources for Parkinson disease (PD) …
international collaboration producing fundamental resources for Parkinson disease (PD) …
Noncanonical functions of the serine‐arginine‐rich splicing factor (SR) family of proteins in development and disease
RE Wagner, M Frye - Bioessays, 2021 - Wiley Online Library
Members of the serine/arginine (SR)‐rich protein family of splicing factors play versatile
roles in RNA processing steps and are often essential for normal development. Dynamic …
roles in RNA processing steps and are often essential for normal development. Dynamic …
Exploring the multifunctionality of SR proteins
I Slišković, H Eich… - Biochemical Society …, 2022 - portlandpress.com
Members of the arginine–serine-rich protein family (SR proteins) are multifunctional RNA-
binding proteins that have emerged as key determinants for mRNP formation, identity and …
binding proteins that have emerged as key determinants for mRNP formation, identity and …
SRSF7 maintains its homeostasis through the expression of Split-ORFs and nuclear body assembly
V Königs, C de Oliveira Freitas Machado… - Nature structural & …, 2020 - nature.com
SRSF7 is an essential RNA-binding protein whose misexpression promotes cancer. Here,
we describe how SRSF7 maintains its protein homeostasis in murine P19 cells using an …
we describe how SRSF7 maintains its protein homeostasis in murine P19 cells using an …
Insights into established and emerging roles of SR protein family in plants and animals
Splicing of pre‐mRNA is an essential part of eukaryotic gene expression. Serine‐/arginine‐
rich (SR) proteins are highly conserved RNA‐binding proteins present in all metazoans and …
rich (SR) proteins are highly conserved RNA‐binding proteins present in all metazoans and …
Splicing of long non-coding RNAs primarily depends on polypyrimidine tract and 5′ splice-site sequences due to weak interactions with SR proteins
Z Krchňáková, PK Thakur, M Krausová… - Nucleic acids …, 2019 - academic.oup.com
Many nascent long non-coding RNAs (lncRNAs) undergo the same maturation steps as pre-
mRNAs of protein-coding genes (PCGs), but they are often poorly spliced. To identify the …
mRNAs of protein-coding genes (PCGs), but they are often poorly spliced. To identify the …