Advances in CLIP technologies for studies of protein-RNA interactions

FCY Lee, J Ule - Molecular cell, 2018 - cell.com
RNA binding proteins (RBPs) regulate all aspects in the life cycle of RNA molecules. To
elucidate the elements that guide RNA specificity, regulatory mechanisms, and functions of …

[HTML][HTML] Serine/arginine-rich splicing factors: the bridge linking alternative splicing and cancer

X Zheng, Q Peng, L Wang, X Zhang… - … journal of biological …, 2020 - ncbi.nlm.nih.gov
The serine/arginine-rich splicing factors (SRs) belong to the serine arginine-rich protein
family, which plays an extremely important role in the splicing process of precursor RNA …

Sequence, structure, and context preferences of human RNA binding proteins

D Dominguez, P Freese, MS Alexis, A Su, M Hochman… - Molecular cell, 2018 - cell.com
RNA binding proteins (RBPs) orchestrate the production, processing, and function of
mRNAs. Here, we present the affinity landscapes of 78 human RBPs using an unbiased …

Differential functions of splicing factors in mammary transformation and breast cancer metastasis

SH Park, M Brugiolo, M Akerman, S Das, L Urbanski… - Cell reports, 2019 - cell.com
Misregulation of alternative splicing is a hallmark of human tumors, yet to what extent and
how it contributes to malignancy are only beginning to be unraveled. Here, we define which …

The Foundational Data Initiative for Parkinson Disease: Enabling efficient translation from genetic maps to mechanism

E Bressan, X Reed, V Bansal, E Hutchins, MM Cobb… - Cell genomics, 2023 - cell.com
Summary The Foundational Data Initiative for Parkinson Disease (FOUNDIN-PD) is an
international collaboration producing fundamental resources for Parkinson disease (PD) …

Noncanonical functions of the serine‐arginine‐rich splicing factor (SR) family of proteins in development and disease

RE Wagner, M Frye - Bioessays, 2021 - Wiley Online Library
Members of the serine/arginine (SR)‐rich protein family of splicing factors play versatile
roles in RNA processing steps and are often essential for normal development. Dynamic …

Exploring the multifunctionality of SR proteins

I Slišković, H Eich… - Biochemical Society …, 2022 - portlandpress.com
Members of the arginine–serine-rich protein family (SR proteins) are multifunctional RNA-
binding proteins that have emerged as key determinants for mRNP formation, identity and …

SRSF7 maintains its homeostasis through the expression of Split-ORFs and nuclear body assembly

V Königs, C de Oliveira Freitas Machado… - Nature structural & …, 2020 - nature.com
SRSF7 is an essential RNA-binding protein whose misexpression promotes cancer. Here,
we describe how SRSF7 maintains its protein homeostasis in murine P19 cells using an …

Insights into established and emerging roles of SR protein family in plants and animals

K Kumar, SK Sinha, U Maity, PB Kirti… - Wiley Interdisciplinary …, 2023 - Wiley Online Library
Splicing of pre‐mRNA is an essential part of eukaryotic gene expression. Serine‐/arginine‐
rich (SR) proteins are highly conserved RNA‐binding proteins present in all metazoans and …

Splicing of long non-coding RNAs primarily depends on polypyrimidine tract and 5′ splice-site sequences due to weak interactions with SR proteins

Z Krchňáková, PK Thakur, M Krausová… - Nucleic acids …, 2019 - academic.oup.com
Many nascent long non-coding RNAs (lncRNAs) undergo the same maturation steps as pre-
mRNAs of protein-coding genes (PCGs), but they are often poorly spliced. To identify the …