The journey from melanocytes to melanoma

PP Centeno, V Pavet, R Marais - Nature Reviews Cancer, 2023 - nature.com
Over the past decade, melanoma has led the field in new cancer treatments, with impressive
gains in on-treatment survival but more modest improvements in overall survival. Melanoma …

[HTML][HTML] Melanin's journey from melanocytes to keratinocytes: Uncovering the molecular mechanisms of melanin transfer and processing

L Bento-Lopes, LC Cabaço, J Charneca… - International journal of …, 2023 - mdpi.com
Skin pigmentation ensures efficient photoprotection and relies on the pigment melanin,
which is produced by epidermal melanocytes and transferred to surrounding keratinocytes …

[HTML][HTML] Biology of melanocytes in mammals

YZ Cui, XY Man - Frontiers in Cell and Developmental Biology, 2023 - frontiersin.org
Melanocytes, which originate from the neuroectoderm, are specialized cells responsible for
producing pigments and possessing a dendritic morphology. These cells migrate to the …

[HTML][HTML] A comprehensive review of mammalian pigmentation: paving the way for innovative hair colour-changing cosmetics

B Fernandes, A Cavaco-Paulo, T Matamá - Biology, 2023 - mdpi.com
Simple Summary The frequency of use of permanent hair dyes to change natural colour are
associated with fibre damage and with an increased risk of serious health problems. The …

The UV‐induced uptake of melanosome by skin keratinocyte is triggered by α7 nicotinic acetylcholine receptor‐mediated phagocytosis

MS Guo, Q Wu, TT Dong, KWK Tsim - The FEBS journal, 2023 - Wiley Online Library
The melanosome is an organelle that produces melanin for skin pigmentation, which is
synthesized by epidermal melanocytes, subsequently transported and internalized by …

[HTML][HTML] Rab3a regulates melanin exocytosis and transfer induced by keratinocyte-conditioned medium

LC Cabaço, L Bento-Lopes, MV Neto, A Ferreira… - JID Innovations, 2022 - Elsevier
Skin pigmentation is imparted by melanin and is crucial for photoprotection against UVR.
Melanin is synthesized and packaged into melanosomes within melanocytes and is then …

UVR promotes keratinocyte phagocytosis and skin pigmentation through TRPA1 channels

Y Liu, Z Li, W Wu, Y Wang, G Zhao, Y Liu… - Clinical, Cosmetic …, 2022 - Taylor & Francis
Purpose Ultraviolet radiation (UVR) enhances skin pigmentation, which involves the
production of melanin by melanocytes and subsequent transfer to keratinocytes. In the …

Photoprotective melanin is maintained within keratinocytes in a storage lysosome

MV Neto, MJ Hall, J Charneca, C Escrevente… - bioRxiv, 2024 - biorxiv.org
In the skin, melanin is synthesized by melanocytes within melanosomes, and transferred to
keratinocytes. After being phagocytosed by keratinocytes, melanin polarizes to supranuclear …

Corrigendum: Comprehensive transcriptomic analysis of critical RNA regulation associated with metabolism and prognosis in clear cell renal carcinoma

S Liu, H Zhou, G Wang, X Lian - Frontiers in cell and developmental …, 2024 - frontiersin.org
In the published article, there was an error in Figure 6C (right down panel) which was
presented for ACHN cells as published. Since it is a bioinformatics paper, we reviewed …

[PDF][PDF] The UV-induced uptake of melanosome by skin keratinocyte is triggered by a7 nicotinic acetylcholine receptor-mediated phagocytosis

MS Guo, Q Wu, TT Dong, KWK Tsim - researchgate.net
The melanosome is an organelle that produces melanin for skin pigmentation, which is
synthesized by epidermal melanocytes, subsequently transported and internalized by …