Dopamine is well recognized as a neurotransmitter in the brain, and regulates critical
functions in a variety of peripheral systems. Growing research has also shown that …

The discovery of the sensory nature of the carotid body dates back to the beginning of the
20th century. Following these seminal discoveries, research into carotid body mechanisms …

In view of the high proportion of individuals with resistance to antihypertensive medication
and/or poor compliance or tolerance of this medication, new drugs to treat hypertension are …

Some of the best biomarkers of age-related cognitive decline are closely linked to synaptic
function and plasticity. This review highlights several age-related synaptic alterations as they …

Pre-clinical research advances our understanding of the vagus nerve-mediated regulation of
immunity and clinical trials successfully utilize electrical vagus nerve stimulation in the …

The enhanced carotid body (CB) chemosensory response to hypoxia induced by chronic
intermittent hypoxia (CIH) has been attributed to oxidative stress, which is expected to …

Emergent evidence indicates that the carotid body (CB) chemoreceptor may sense systemic
inflammatory molecules and is an afferent arm of the anti-inflammatory reflex. Moreover, a …

Carotid bodies (CBs) are peripheral chemoreceptors that sense changes in blood O2, CO2,
and pH levels. Apart from ventilatory control, these organs are deeply involved in the …

Sepsis progresses to multiple organ dysfunction due to the uncontrolled release of
inflammatory mediators, and a growing body of evidence shows that neural signals play a …

Key points We have previously shown that carotid body stimulation by lysophosphatidic acid
elicits a reflex stimulation of vagal efferent activity sufficient to cause bronchoconstriction in …