Background: Cardiovascular risk in diabetes remains elevated despite glucose-lowering
therapies. We hypothesized that hyperglycemia induces trained immunity in macrophages …

Summary RNA polymerase II (RNAPII) pausing in early elongation is critical for gene
regulation. Paused RNAPII can be released into productive elongation by the kinase P-TEFb …

Abiotic environmental stresses are important factors that limit the growth, fiber yield, and
quality of cotton. In this study, an integrative meta-analysis and a system-biology analysis …

Motivation: Advances in high-throughput sequencing have resulted in rapid growth in large,
high-quality datasets including those arising from transcription factor (TF) ChIP-seq …

Mitochondrial diseases and aging are associated with defects in the oxidative
phosphorylation machinery (OXPHOS), which are the only complexes composed of proteins …

The MEME Suite is a powerful, integrated set of web-based tools for studying sequence
motifs in proteins, DNA and RNA. Such motifs encode many biological functions, and their …

Environmental stresses greatly limit crop yield. With the increase in extreme weather events
due to climate change and the constant pressure of diseases and pests, there is an urgent …

Motivation RNA-binding proteins (RBPs) take over 5–10% of the eukaryotic proteome and
play key roles in many biological processes, eg gene regulation. Experimental detection of …

Identifying co-expressed gene clusters can provide evidence for genetic or physical
interactions. Thus, co-expression clustering is a routine step in large-scale analyses of gene …

ChIP-Seq (chromatin immunoprecipitation sequencing) has provided the advantage for
finding motifs as ChIP-Seq experiments narrow down the motif finding to binding site …