The hallmarks of successful anticancer immunotherapy
Immunotherapy is revolutionizing the clinical management of multiple tumors. However, only
a fraction of patients with cancer responds to immunotherapy, and currently available …
a fraction of patients with cancer responds to immunotherapy, and currently available …
NK cell-based immune checkpoint inhibition
Immunotherapy, with an increasing number of therapeutic dimensions, is becoming an
important mode of treatment for cancer patients. The inhibition of immune checkpoints …
important mode of treatment for cancer patients. The inhibition of immune checkpoints …
Regulation and modulation of antitumor immunity in pancreatic cancer
J Leinwand, G Miller - Nature immunology, 2020 - nature.com
Pancreatic ductal adenocarcinoma carries a dismal prognosis, and outcomes have
improved little with modern therapeutics. Checkpoint-based immunotherapy has failed to …
improved little with modern therapeutics. Checkpoint-based immunotherapy has failed to …
Immune checkpoint molecules in natural killer cells as potential targets for cancer immunotherapy
Y Cao, X Wang, T Jin, Y Tian, C Dai… - Signal transduction and …, 2020 - nature.com
Recent studies have demonstrated the potential of natural killer (NK) cells in immunotherapy
to treat multiple types of cancer. NK cells are innate lymphoid cells that play essential roles …
to treat multiple types of cancer. NK cells are innate lymphoid cells that play essential roles …
[HTML][HTML] Auranofin reveals therapeutic anticancer potential by triggering distinct molecular cell death mechanisms and innate immunity in mutant p53 non-small cell …
Auranofin (AF) is an FDA-approved antirheumatic drug with anticancer properties that acts
as a thioredoxin reductase 1 (TrxR) inhibitor. The exact mechanisms through which AF …
as a thioredoxin reductase 1 (TrxR) inhibitor. The exact mechanisms through which AF …
[HTML][HTML] The importance of immune checkpoints in immune monitoring: A future paradigm shift in the treatment of cancer
H Alemohammad, B Najafzadeh, Z Asadzadeh… - Biomedicine & …, 2022 - Elsevier
The growth and development of cancer are directly correlated to the suppression of the
immune system. A major breakthrough in cancer immunotherapy depends on various …
immune system. A major breakthrough in cancer immunotherapy depends on various …
Topological identification and interpretation for single-cell gene regulation elucidation across multiple platforms using scMGCA
Single-cell RNA sequencing provides high-throughput gene expression information to
explore cellular heterogeneity at the individual cell level. A major challenge in characterizing …
explore cellular heterogeneity at the individual cell level. A major challenge in characterizing …
Cold atmospheric plasma-treated PBS eliminates immunosuppressive pancreatic stellate cells and induces immunogenic cell death of pancreatic cancer cells
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers with a low
response to treatment and a five-year survival rate below 5%. The ineffectiveness of …
response to treatment and a five-year survival rate below 5%. The ineffectiveness of …
Netrin G1 promotes pancreatic tumorigenesis through cancer-associated fibroblast–driven nutritional support and immunosuppression
R Francescone, D Barbosa Vendramini-Costa… - Cancer discovery, 2021 - AACR
Pancreatic ductal adenocarcinoma (PDAC) has a poor 5-year survival rate and lacks
effective therapeutics. Therefore, it is of paramount importance to identify new targets. Using …
effective therapeutics. Therefore, it is of paramount importance to identify new targets. Using …
Targeting checkpoint receptors and molecules for therapeutic modulation of natural killer cells
N Kim, HS Kim - Frontiers in Immunology, 2018 - frontiersin.org
Among the most promising therapeutic modalities for cancer treatment is the blockade of
immune checkpoint pathways, which are frequently co-opted by tumors as a major …
immune checkpoint pathways, which are frequently co-opted by tumors as a major …