Metabolic reprogramming occurs in tumors to foster cancer cell proliferation, survival and
metastasis, but as well at a systemic level affecting the whole organism, eventually leading …

The N‐end rule relates the regulation of the in vivo half‐life of a protein to the identity of its N‐
terminal residue. Degradation signals (degrons) that are targeted by the N‐end rule pathway …

All intracellular proteins and many extracellular proteins are continually “turning over;” ie,
they are being hydrolyzed to their constituent amino acids and replaced by new synthesis …

Muscle wasting is a debilitating consequence of fasting, inactivity, cancer, and other
systemic diseases that results primarily from accelerated protein degradation by the …

Skeletal muscle atrophy is a debilitating response to starvation and many systemic diseases
including diabetes, cancer, and renal failure. We had proposed that a common set of …

Skeletal muscle hypertrophy is defined as an increase in muscle mass, which in the adult
animal comes as a result of an increase in the size, as opposed to the number, of pre …

Skeletal muscle atrophy is defined as a decrease in muscle mass and it occurs when protein
degradation exceeds protein synthesis. Potential triggers of muscle wasting are long-term …

Atrophy of skeletal muscle is a serious consequence of numerous diseases, including
cancer and AIDS. Successful treatments for skeletal muscle atrophy could either block …

With trauma, sepsis, cancer, or uremia, animals or patients experience accelerated
degradation of muscle protein in the ATP-ubiquitin-proteasome (Ub-P'some) system. The …

Atrogin1/MAFbx is an ubiquitin ligase that mediates muscle atrophy in a variety of catabolic
states. We recently found that H 2 O 2 stimulates atrogin1/MAFbx gene expression. Since …