Uterine fibroids: the elephant in the room
CL Walker, EA Stewart - Science, 2005 - science.org
Uterine fibroids (leiomyomas) have historically been viewed as important chiefly as the
major indication for hysterectomy. As new therapies are developed, the heterogeneity of this …
major indication for hysterectomy. As new therapies are developed, the heterogeneity of this …
Growth factors and myometrium: biological effects in uterine fibroid and possible clinical implications
BACKGROUND Growth factors are proteins secreted by a number of cell types that are
capable of modulating cellular growth, proliferation and cellular differentiation. It is well …
capable of modulating cellular growth, proliferation and cellular differentiation. It is well …
miR-200 family and targets, ZEB1 and ZEB2, modulate uterine quiescence and contractility during pregnancy and labor
NE Renthal, CC Chen, KC Williams… - Proceedings of the …, 2010 - National Acad Sciences
Throughout most of pregnancy, uterine quiescence is maintained by increased
progesterone receptor (PR) transcriptional activity, whereas spontaneous labor is …
progesterone receptor (PR) transcriptional activity, whereas spontaneous labor is …
Progesterone receptor-A and-B have opposite effects on proinflammatory gene expression in human myometrial cells: implications for progesterone actions in human …
H Tan, L Yi, NS Rote, WW Hurd… - The Journal of Clinical …, 2012 - academic.oup.com
Context: Progesterone promotes uterine relaxation during pregnancy and its withdrawal
induces labor. Progesterone withdrawal in human parturition is mediated in part by changes …
induces labor. Progesterone withdrawal in human parturition is mediated in part by changes …
Molecular evidence of functional progesterone withdrawal in human myometrium
L Nadeem, O Shynlova, E Matysiak-Zablocki… - Nature …, 2016 - nature.com
Progesterone suppresses uterine contractility acting through its receptors (PRA/B). The
mechanism by which human labour is initiated in the presence of elevated circulating …
mechanism by which human labour is initiated in the presence of elevated circulating …
A novel immortalized human endometrial stromal cell line with normal progestational response
Obtaining primary human endometrial stromal cells (HESCs) for in vitro studies is limited by
the scarcity of adequate human material and the inability to passage these cells in culture for …
the scarcity of adequate human material and the inability to passage these cells in culture for …
Progesterone receptor plays a major antiinflammatory role in human myometrial cells by antagonism of nuclear factor-κB activation of cyclooxygenase 2 expression
Spontaneous labor in women and in other mammals is likely mediated by a concerted series
of biochemical events that negatively impact the ability of the progesterone receptor (PR) to …
of biochemical events that negatively impact the ability of the progesterone receptor (PR) to …
Up-regulation of the progesterone receptor (PR)-C isoform in laboring myometrium by activation of nuclear factor-κB may contribute to the onset of labor through …
Progesterone acting via the progesterone receptor (PR) plays a critical role in maintaining
uterine quiescence during pregnancy. In the present study, we tested the hypothesis that the …
uterine quiescence during pregnancy. In the present study, we tested the hypothesis that the …
Engineered MED12 mutations drive leiomyoma-like transcriptional and metabolic programs by altering the 3D genome compartmentalization
Nearly 70% of Uterine fibroid (UF) tumors are driven by recurrent MED12 hotspot mutations.
Unfortunately, no cellular models could be generated because the mutant cells have lower …
Unfortunately, no cellular models could be generated because the mutant cells have lower …