Techniques to assess bone ultrastructure organization: orientation and arrangement of mineralized collagen fibrils

M Georgiadis, R Müller… - Journal of the Royal …, 2016 - royalsocietypublishing.org
Bone's remarkable mechanical properties are a result of its hierarchical structure. The
mineralized collagen fibrils, made up of collagen fibrils and crystal platelets, are bone's …

Lacunar-canalicular bone remodeling: Impacts on bone quality and tools for assessment

G Vahidi, C Rux, VD Sherk, CM Heveran - Bone, 2021 - Elsevier
Osteocytes can resorb as well as replace bone adjacent to the expansive lacunar-
canalicular system (LCS). Suppressed LCS remodeling decreases bone fracture toughness …

Nanostructure surveys of macroscopic specimens by small-angle scattering tensor tomography

M Liebi, M Georgiadis, A Menzel, P Schneider… - Nature, 2015 - nature.com
The mechanical properties of many materials are based on the macroscopic arrangement
and orientation of their nanostructure. This nanostructure can be ordered over a range of …

Investigation of the three-dimensional orientation of mineralized collagen fibrils in human lamellar bone using synchrotron X-ray phase nano-tomography

P Varga, A Pacureanu, M Langer, H Suhonen, B Hesse… - Acta biomaterialia, 2013 - Elsevier
We investigate the three-dimensional (3-D) organization of mineralized collagen fibrils in
human cortical bone based on synchrotron X-ray phase nano-tomography images. In …

[HTML][HTML] 3D Raman mapping of the collagen fibril orientation in human osteonal lamellae

S Schrof, P Varga, L Galvis, K Raum, A Masic - Journal of structural biology, 2014 - Elsevier
Chemical composition and fibrillar organization are the major determinants of osteonal bone
mechanics. However, prominent methodologies commonly applied to investigate …

[PDF][PDF] Small-angle X-ray scattering tensor tomography: Model of the three-dimensional reciprocal-space map, reconstruction algorithm and angular sampling …

M Liebi, M Georgiadis, J Kohlbrecher… - … A: Foundations and …, 2018 - journals.iucr.org
Small-angle X-ray scattering tensor tomography, which allows reconstruction of the local
three-dimensional reciprocal-space map within a three-dimensional sample as introduced …

[PDF][PDF] Small-angle scattering tensor tomography algorithm for robust reconstruction of complex textures

LC Nielsen, P Erhart, M Guizar-Sicairos… - … Section A: Foundations …, 2023 - journals.iucr.org
The development of small-angle scattering tensor tomography has enabled the study of
anisotropic nanostructures in a volume-resolved manner. It is of great value to have …

3D scanning SAXS: A novel method for the assessment of bone ultrastructure orientation

M Georgiadis, M Guizar-Sicairos, A Zwahlen… - Bone, 2015 - Elsevier
The arrangement and orientation of the ultrastructure plays an important role for the
mechanical properties of inhomogeneous and anisotropic materials, such as polymers …

Microfibril orientation dominates the microelastic properties of human bone tissue at the lamellar length scale

M Granke, A Gourrier, F Rupin, K Raum, F Peyrin… - PLoS …, 2013 - journals.plos.org
The elastic properties of bone tissue determine the biomechanical behavior of bone at the
organ level. It is now widely accepted that the nanoscale structure of bone plays an …

[HTML][HTML] On the amorphous layer in bone mineral and biomimetic apatite: a combined small-and wide-angle X-ray scattering analysis

F Bertolotti, FJ Carmona, G Dal Sasso… - Acta biomaterialia, 2021 - Elsevier
The occurrence of an amorphous calcium phosphate layer covering the crystalline apatite
core has been suggested to be an intrinsic feature of both bone mineral and synthetic …