After its discovery in the early 1980s, the natriuretic peptide (NP) system has been
extensively characterized and its potential influence in the development and progression of …

It is important that the medical profession play a significant role in critically evaluating the
use of diagnostic procedures and therapies as they are introduced and tested in the …

1.1. Methodology and Evidence Review The recommendations listed in this document are,
whenever possible, evidence based. An extensive evidence review was conducted through …

The recommendations listed in this document are, whenever possible, evidence based. An
extensive evidence review was conducted through October 2011 and includes selected …

Context Guidelines recommend that exercise training be considered for medically stable
outpatients with heart failure. Previous studies have not had adequate statistical power to …

In recent years quality of life instruments have been featured as primary outcomes in many
randomized trials. One of the challenges facing the investigator using such measures is …

Background Previous studies have suggested that cardiac resynchronization achieved
through atrial-synchronized biventricular pacing produces clinical benefits in patients with …

Heart failure (HF) is a major and growing public health problem in the United States.
Approximately 5 million patients in this country have HF, and over 550 000 patients are …

Objective.—To evaluate the effect of angiotensin-converting enzyme (ACE) inhibitors on
mortality and morbidity in patients with symptomatic congestive heart failure. Data Sources …

Objectives: The purpose of this study was to quantitatively assess the relationship between
therapy-induced changes in left ventricular (LV) remodeling and longer-term outcomes in …