ABCA4 is a member of the superfamily of ATP-binding cassette (ABC) transporters that is
preferentially localized along the rim region of rod and cone photoreceptor outer segment …

To serve vision, vertebrate rod and cone photoreceptors must detect photons, convert the
light stimuli into cellular signals, and then convey the encoded information to downstream …

Retinitis pigmentosa (RP) and allied diseases are heterogeneous clinically and genetically.
Here we summarize the retinal cell types involved in these diseases, the large number of …

A diverse group of animals, including members of most major phyla, have adapted to life in
the perpetual darkness of caves. These animals are united by the convergence of two …

Outer segments of mammalian rod photoreceptor cells contain an abundantly expressed
membrane protein that migrates with an apparent molecular mass of 220 kDa by SDS-gel …

Retinitis pigmentosa (RP) denotes a group of hereditary retinal dystrophies, characterized
by the early onset of night blindness followed by a progressive loss of the visual field. The …

Peripherin/rds is an integral membrane glycoprotein, mainly located in the rod and cone
outer segments. The relevance of this protein to photoreceptor outer segment morphology …

Cave animals are excellent models to study the general principles of evolution as well as the
mechanisms of adaptation to a novel environment: the perpetual darkness of caves. In this …

ABCA4 is a member of the ABCA subfamily of ATP binding cassette (ABC) transporters that
is expressed in rod and cone photoreceptors of the vertebrate retina. ABCA4, also known as …

PURPOSE: To measure the proportion of cases of retinitis pigmentosa (RP) caused by
mutations in the peripherin/RDS (RDS) and ROM1 genes. METHODS: The single-strand …