Since the proposal of the differential adhesion hypothesis, scientists have been fascinated
by how cell adhesion mediates cellular self-organization to form spatial patterns during …

Mammalian hearing requires the development of the organ of Corti, a sensory epithelium
comprising unique cell types. The limited number of each of these cell types, combined with …

In mammals, hair cells and spiral ganglion neurons (SGNs) in the cochlea together are
sophisticated “sensorineural” structures that transduce auditory information from the outside …

Cell adhesion molecules are membrane-bound proteins predominantly expressed in the
central nervous system along principal axonal pathways with key roles in nervous system …

The sensory epithelium of the mammalian cochlea, the organ of Corti, is comprised of at
least seven unique cell types including two functionally distinct types of mechanosensory …

During nervous system development, axons often undergo elaborate changes in branching
patterns before circuits have achieved their mature patterns of innervation. In the auditory …

Background Proteomic approaches are central in biomarker discovery. While mass-
spectrometry-based techniques are widely used, novel targeted proteomic platforms have …

Glucocorticoids are the first-line treatment for sensorineural hearing loss, but little is known
about the mechanism of their protective effect or the impact of route of administration. The …

The inner ear sensory neurons play a pivotal role in auditory processing and balance
control. Though significant progresses have been made, the underlying mechanisms …

Propionic and methylmalonic acidemias (PAcidemia and MMAcidemia, respectively) are
genetic disorders characterized by acute metabolic decompensation and neurological …