Pulmonary hypertension (PH) is characterized by pulmonary artery remodeling that can
subsequently culminate in right heart failure and premature death. Emerging evidence …

Hypoxia-inducible factors (HIFs) are transcriptional activators that function as master
regulators of oxygen homeostasis, which is disrupted in disorders affecting the circulatory …

Hypoxia-inducible factors (HIFs) regulate the transcription of genes that mediate the
response to hypoxia. HIFs are constantly expressed and degraded under normoxia, but …

Hypoxic pulmonary hypertension (PH) comprises a heterogeneous group of diseases
sharing the common feature of chronic hypoxia-induced pulmonary vascular remodeling …

Hypoxic pulmonary vasoconstriction is correlated with pulmonary vascular remodeling. The
hypoxia-inducible transcription factors (HIFs) HIF-1α and HIF-2α are known to contribute to …

Alveolarization is the process by which the alveoli, the principal gas exchange units of the
lung, are formed. Along with the maturation of the pulmonary vasculature, alveolarization is …

Hypoxia inducible factors (HIFs) are α/β heterodimeric transcription factors that direct
multiple cellular and systemic responses in response to changes in oxygen availability. The …

Increased mitochondrial reactive oxygen species (mROS) and glycolysis have been
established in pulmonary hypertension (PH). However, the effect of elevated mROS on …

The circulation of the lung is unique both in volume and function. For example, it is the only
organ with two circulations: the pulmonary circulation, the main function of which is gas …

Hypoxia signaling plays a major role in non-malignant and malignant hyperproliferative
diseases. Pulmonary hypertension (PH), a hypoxia-driven vascular disease, is characterized …