Although awareness of familial hypercholesterolemia (FH) is increasing, this common,
potentially fatal, treatable condition remains underdiagnosed. Despite FH being a genetic …

Cascade testing is the process of offering genetic counseling and testing to at-risk relatives
of an individual who has been diagnosed with a genetic condition. It is critical for increasing …

Hyperlipidemia, the most common form of dyslipidemia, is the main source of cardiovascular
disorders, characterized by elevated level of total cholesterol (TC), triglycerides (TG) and low …

Abstract Purpose of Review The cardiovascular (CV) risk related to lipid disorders is well
established and is based on a robust body of evidence from well-designed randomized …

Objectives Individuals with heterozygous familial hypercholesterolaemia (FH) are at high
risk of developing cardiovascular disease (CVD). This risk can be substantially reduced with …

Abstract Purpose of Review Cascade testing, or screening, is the process of stepwise,
systematic genetic testing of at-risk relatives for a genetic variant originally identified in a …

Background: The MyCode Community Health Initiative (MyCode) is returning actionable
results from whole exome sequencing. Familial hypercholesterolemia (FH) is an inherited …

Familial hypercholesterolaemia (FH) is a dominantly inherited disorder of low-density
lipoprotein (LDL) catabolism, which if untreated causes lifelong elevated LDL-cholesterol …

Background: Familial hypercholesterolemia (FH) is predominantly caused by mutations in
the 4 FH candidate genes (FHCGs), namely, low-density lipoprotein receptor (LDLR) …

Familial hypercholesterolemia (FH) is a serious inherited disorder, which greatly increases
individuals' risk of cardiovascular disease (CVD) in adult life. However, medical treatment …