Targeted delivery to tumors: multidirectional strategies to improve treatment efficiency

OM Kutova, EL Guryev, EA Sokolova, R Alzeibak… - Cancers, 2019 - mdpi.com
Malignant tumors are characterized by structural and molecular peculiarities providing a
possibility to directionally deliver antitumor drugs with minimal impact on healthy tissues and …

Diagnostic and therapeutic approaches for glioblastoma and neuroblastoma cancers using chlorotoxin nanoparticles

T Boltman, M Meyer, O Ekpo - Cancers, 2023 - mdpi.com
Simple Summary Glioblastoma multiforme (GB) and neuroblastomas (NBs) are nervous
system cancers that are difficult to diagnosis and treat. Chlorotoxin (CTX), is a peptide …

Diversity of potassium channel ligands: focus on scorpion toxins

AI Kuzmenkov, EV Grishin, AA Vassilevski - Biochemistry (Moscow), 2015 - Springer
Potassium (K+) channels are a widespread superfamily of integral membrane proteins that
mediate selective transport of K+ ions through the cell membrane. They have been found in …

Labelled animal toxins as selective molecular markers of ion channels: Applications in neurobiology and beyond

AI Kuzmenkov, AA Vassilevski - Neuroscience Letters, 2018 - Elsevier
Animal toxins are traditional and indispensible molecular tools that find application in
different fields of biochemistry, neurobiology and pharmacology. These compounds possess …

Expanding the pharmacological profile of κ-hefutoxin 1 and analogues: A focus on the inhibitory effect on the oncogenic channel Kv10. 1

L Moreels, S Peigneur, Y Yamaguchi, K Vriens… - Peptides, 2017 - Elsevier
Peptide toxins, such as scorpion peptides, are interesting lead compounds in the search for
novel drugs. In this paper, the focus is on the scorpion peptide κ-hefutoxin 1. This peptide …

[HTML][HTML] Venom peptides–A comprehensive translational perspective in pain management

V Vidya, RR Achar, MU Himathi, N Akshita… - Current Research in …, 2021 - Elsevier
Venom peptides have been evolving complex therapeutic interventions that potently and
selectively modulate a range of targets such as ion channels, receptors, and signaling …

Chemical synthesis and functional characterization of LaIT3, an insecticidal two-domain peptide in Liocheles australasiae venom

S Sakai, Y Fujita, H Juichi, Y Nakagawa, M Miyashita - Toxicon, 2024 - Elsevier
LaIT3, belonging to the β-KTx family, is an insecticidal peptide in the venom of the Liocheles
australasiae scorpion. Peptides in the family consist of two structural domains: an N-terminal …

Trancriptomic approach reveals the molecular diversity of Hottentotta conspersus (Buthidae) venom

BG Mille, S Peigneur, R Predel, J Tytgat - Toxicon, 2015 - Elsevier
Scorpion venom consists of a complex mixture of molecules including biologically active
compounds. Because of their high potency and selectivity, toxins have medical applicability …

Surface-decoration strategies in nanomedicine for cancer treatment

S Parveen, S Fatima, SN Quadri, S Beg… - … Strategies for Cancer …, 2021 - Elsevier
Nanotechnology has gained major interest in cancer therapeutics mainly on account of the
imploring characteristic properties that nanoparticles exhibit. These include protection …

[PDF][PDF] ANDROCTONUS CRASSİCAUDA AKREP ZEHRİNİN ANTİKANSER ÖZELLİĞİNİN İNCELENMESİ

M Tiken - 2022 - acikerisim.harran.edu.tr
Günümüzde çağımızın öldürücü hastalığı olan kansere karşı yapılan klasik tıbbi ilaç
tedavilerinde kalıcı ve iyileştirici sonuçlar alınamamaktadır. Ayrıca gücünü doğal ürünlerden …