Background Tauopathies are a class of neurodegenerative disorders characterized by
neuronal and/or glial tau-positive inclusions. Main body Clinically, tauopathies can present …

Tauopathies are a heterogeneous class of neurodegenerative diseases characterized by
intracellular inclusions of aggregated tau proteins. Tau aggregates in different tauopathies …

Heterozygous hTau mice were used for the study of tau seeding. These mice express the six
human tau isoforms, with a high predominance of 3Rtau over 4Rtau. The following groups …

Individuals with Down syndrome (DS) exhibit Alzheimer's disease (AD) pathology at a young
age, including amyloid plaques and neurofibrillary tangles (NFTs). Tau pathology can …

Abstract Alzheimer's disease (AD)-related neurofibrillary tangles (NFT), argyrophilic grain
disease (AGD), aging-related tau astrogliopathy (ARTAG), limbic predominant TDP-43 …

Tauopathies are a clinically and neuropathologically heterogeneous group of
neurodegenerative disorders, characterized by abnormal tau aggregates. Tau, a …

Alzheimer disease is one of the most challenging demons in our society due to its very high
prevalence and its clinical manifestations which cause deterioration of cognition …

Several studies have demonstrated the different characteristics of tau seeding and
spreading following intracerebral inoculation in murine models of tau-enriched fractions of …

The cellular prion protein (PrPC) plays many roles in the developing and adult brain. In
addition, PrPC binds to several amyloids in oligomeric and prefibrillar forms and may act as …

The transcellular propagation of the aberrantly modified protein tau along the functional
brain network is a key hallmark of Alzheimer's disease and related tauopathies. Inoculation …