Microglia are the primary innate immune cells in the CNS. In the healthy brain, they exhibit a
unique molecular homeostatic 'signature', consisting of a specific transcriptional profile and …

Microglia are the main resident macrophage population of the CNS and perform numerous
functions required for CNS development, homeostasis, immunity, and repair. Many lines of …

Cancer-associated fibroblasts (CAFs) are the predominant components of the tumor
microenvironment (TME) and influence cancer hallmarks, but without systematic …

Summary Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract
infection, however, a subset of patients progress to severe disease and respiratory failure …

Microglia are emerging as key drivers of neurological diseases. However, we lack a
systematic understanding of the underlying mechanisms. Here, we present a screening …

Macrophages are key innate immune cells in the tumor microenvironment (TME) that
regulate primary tumor growth, vascularization, metastatic spread and tumor response to …

An early analysis of circulating monocytes may be critical for predicting COVID-19 course
and its sequelae. In 131 untreated, acute COVID-19 patients at emergency room arrival …

Glucocorticoids (GCs) exert potent anti-inflammatory effects in immune cells through the
glucocorticoid receptor (GR). Dendritic cells (DCs), central actors for coordinating immune …

The transcription factor MafB regulates macrophage differentiation. However, studies on the
phenotype of Mafb-deficient macrophages are still limited. Recently, it was shown that the …

Recent advances in genetic analysis and intensive research have revealed that microglial
cells respond to external stimuli in various ways and adopt diverse states. Herein, we …