The tobacco smoke component, acrolein, as a major culprit in lung diseases and respiratory cancers: Molecular mechanisms of acrolein cytotoxic activity
P Hikisz, D Jacenik - Cells, 2023 - mdpi.com
Acrolein, a highly reactive unsaturated aldehyde, is a ubiquitous environmental pollutant
that seriously threatens human health and life. Due to its high reactivity, cytotoxicity and …
that seriously threatens human health and life. Due to its high reactivity, cytotoxicity and …
Molecular mechanisms of acrolein toxicity: relevance to human disease
A Moghe, S Ghare, B Lamoreau… - Toxicological …, 2015 - academic.oup.com
Acrolein, a highly reactive unsaturated aldehyde, is a ubiquitous environmental pollutant
and its potential as a serious environmental health threat is beginning to be recognized …
and its potential as a serious environmental health threat is beginning to be recognized …
Oxidative stress and redox regulation of lung inflammation in COPD
Reactive oxygen species, either directly or via the formation of lipid peroxidation products,
may play a role in enhancing inflammation through the activation of stress kinases (c-Jun …
may play a role in enhancing inflammation through the activation of stress kinases (c-Jun …
Advanced lipid peroxidation end products in oxidative damage to proteins. Potential role in diseases and therapeutic prospects for the inhibitors
A Negre‐Salvayre, C Coatrieux… - British journal of …, 2008 - Wiley Online Library
Reactive carbonyl compounds (RCCs) formed during lipid peroxidation and sugar
glycoxidation, namely Advanced lipid peroxidation end products (ALEs) and Advanced …
glycoxidation, namely Advanced lipid peroxidation end products (ALEs) and Advanced …
Pathological aspects of lipid peroxidation
A Negre-Salvayre, N Auge, V Ayala, H Basaga… - Free radical …, 2010 - Taylor & Francis
Lipid peroxidation (LPO) product accumulation in human tissues is a major cause of tissular
and cellular dysfunction that plays a major role in ageing and most age-related and …
and cellular dysfunction that plays a major role in ageing and most age-related and …
[HTML][HTML] Membrane phospholipids, lipoxidative damage and molecular integrity: a causal role in aging and longevity
R Pamplona - Biochimica et Biophysica Acta (BBA)-Bioenergetics, 2008 - Elsevier
Nonenzymatic molecular modifications induced by reactive carbonyl species (RCS)
generated by peroxidation of membrane phospholipids acyl chains play a causal role in the …
generated by peroxidation of membrane phospholipids acyl chains play a causal role in the …
Redox-sensitive kinases of the nuclear factor-κB signaling pathway
C Pantano, NL Reynaert, AVD Vliet… - Antioxidants & redox …, 2006 - liebertpub.com
NF-κB is an inducible transcription factor that plays a role in the expression of over one
hundred genes involved in immunity, inflammation, proliferation, and in defense against …
hundred genes involved in immunity, inflammation, proliferation, and in defense against …
Acrolein–a pulmonary hazard
K Bein, GD Leikauf - Molecular nutrition & food research, 2011 - Wiley Online Library
Acrolein is a respiratory irritant that can be generated during cooking and is in
environmental tobacco smoke. More plentiful in cigarette smoke than polycyclic aromatic …
environmental tobacco smoke. More plentiful in cigarette smoke than polycyclic aromatic …
Ammonia induces Treg/Th1 imbalance with triggered NF-κB pathway leading to chicken respiratory inflammation response
Q Shi, W Wang, M Chen, H Zhang, S Xu - Science of the total environment, 2019 - Elsevier
Ammonia (NH 3) is a severe air pollutant and a component of haze (PM2. 5). The respiratory
tract is the first route of exogenous ammonia's entry into the human and animal body. Many …
tract is the first route of exogenous ammonia's entry into the human and animal body. Many …
Interleukin-1β induction of NFκB is partially regulated by H2O2-mediated activation of NFκB-inducing kinase
Q Li, JF Engelhardt - Journal of Biological Chemistry, 2006 - ASBMB
Reactive oxygen species (ROS) have been demonstrated to act as second messengers in a
number of signal transduction pathways, including NFκB. However, the mechanism (s) by …
number of signal transduction pathways, including NFκB. However, the mechanism (s) by …